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Articles Published Processes
8/14/2017 4:00:08 AM | Browse: 1001 | Download: 1374
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Received |
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2017-03-16 09:02 |
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Peer-Review Started |
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2017-03-17 14:12 |
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To Make the First Decision |
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2017-05-12 09:25 |
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Return for Revision |
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2017-05-16 09:02 |
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Revised |
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2017-05-26 23:09 |
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Second Decision |
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2017-06-27 00:39 |
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Accepted by Journal Editor-in-Chief |
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2017-06-29 02:03 |
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Accepted by Company Editor-in-Chief |
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2017-07-04 06:13 |
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Articles in Press |
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2017-07-04 06:13 |
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Publication Fee Transferred |
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2017-07-07 04:55 |
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Edit the Manuscript by Language Editor |
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2017-07-14 01:25 |
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Typeset the Manuscript |
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2017-08-03 02:29 |
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Publish the Manuscript Online |
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2017-08-14 04:00 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Autophagic cell death induced by reactive oxygen species is involved in hyperthermic sensitization to ionizing radiation in human hepatocellular carcinoma cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Guang-Jin Yuan, Jun-Jian Deng, De-Dong Cao, Lei Shi, Xin Chen, Jin-Ju Lei and Xi-Ming Xu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Program Project Funds of Chongqing |
2013-2-179 |
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| Corresponding Author |
Xi-Ming Xu, PhD, Professor, Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China. rm001271@whu.edu.cn |
| Key Words |
Autophagic cell death; Hyperthermia; Ionizing radiation; Hepatocellular carcinoma; Reactive oxygen species |
| Core Tip |
Increased cell autophagy and intracellular reactive oxygen species (ROS), accompanied by decreased cell viability and surviving fraction, were observed in HepG2 cells treated with hyperthermia and ionizing radiation. Pretreatment with N-acetylcysteine, an ROS scavenger, markedly inhibited the above cytotoxicity and cell autophagy. The results suggest that autophagic cell death is involved in the hyperthermic sensitization to ionizing radiation, and its induction may be due to the increased intracellular ROS. |
| Publish Date |
2017-08-14 04:00 |
| Citation |
Yuan GJ, Deng JJ, Cao DD, Shi L, Chen X, Lei JJ, Xu XM. Autophagic cell death induced by reactive oxygen species is involved in hyperthermic sensitization to ionizing radiation in human hepatocellular carcinoma cells. World J Gastroenterol 2017; 23(30): 5530-5537 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i30/5530.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i30.5530 |
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