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9/28/2017 10:01:54 AM | Browse: 773 | Download: 1057
Publication Name World Journal of Gastroenterology
Manuscript ID 34004
Country/Territory United States
Received
2017-03-21 10:26
Peer-Review Started
2017-03-22 17:30
To Make the First Decision
2017-04-21 10:02
Return for Revision
2017-04-27 20:49
Revised
2017-05-12 02:59
Second Decision
2017-07-12 09:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-07-24 08:01
Articles in Press
2017-07-24 08:01
Publication Fee Transferred
2017-09-07 02:41
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-09-23 07:39
Publish the Manuscript Online
2017-09-28 10:01
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis
Manuscript Source Unsolicited Manuscript
All Author List Janaki K Iyer, Mamta Kalra, Anil Kaul, Mark E Payton and Rashmi Kaul
Funding Agency and Grant Number
Corresponding Author Rashmi Kaul, PhD, Associate Professor, Department of Biochemistry and Microbiology, Oklahoma State University - Center for Health Sciences, Tulsa, OK 74012, United States. rashmi.kaul10@okstate.edu
Key Words Estrogen receptor α; Estrogen receptor β; Hepatitis C virus-related cirrhosis; Hepatitis C virus-related hepatocellular carcinoma; Sex and gender; Normal liver
Core Tip Our study, for the first time, demonstrates gender-based differences in basal expression of estrogen receptor α (ERα) in the liver of normal males and females. Altered nuclear and cytoplasm liver ER subtype protein expression was also observed in hepatitis C virus (HCV)-cirrhosis and HCV-related hepatocellular carcinoma (HCC) that correlate with the inflammatory and oncogenic markers activated NF-κB and cyclin D1 implicating their role in chronic cirrhosis and malignant transformation. These findings may have an impact on future planning strategies for the development of novel treatments or prognostic markers by targeting ERs or their signaling pathways during chronic HCV-related cirrhosis and HCC development.
Publish Date 2017-09-28 10:01
Citation Iyer JK, Kalra M, Kaul A, Payton ME, Kaul R. Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis. World J Gastroenterol 2017; 23(37): 6802-6816
URL http://www.wjgnet.com/1007-9327/full/v23/i37/6802.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i37.6802
Full Article (PDF) WJG-23-6802.pdf
Full Article (Word) WJG-23-6802.doc
Manuscript File 34004-Review.docx
Answering Reviewers 34004-Answering reviewers.pdf
Audio Core Tip 34004-Audio core tip.mp3
Biostatistics Review Certificate 34004-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 34004-Conflict-of-interest statement.pdf
Copyright License Agreement 34004-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 34004-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 34004-Institutional review board statement.pdf
Supplementary Material 34004-Supplementary material.pdf
Peer-review Report 34004-Peer-review(s).pdf
Scientific Misconduct Check 34004-Scientific misconduct check.pdf
Scientific Editor Work List 34004-Scientific editor work list.pdf