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9/14/2017 3:13:08 AM | Browse: 85 | Download: 26
Publication Name World Journal of Gastroenterology
Manuscript ID 34114
Country of Manuscript Source China
2017-03-28 17:41
Peer-Review Started
2017-04-01 12:13
To Make the First Decision
2017-04-26 08:48
Return for Revision
2017-04-28 11:21
2017-05-15 09:19
Second Decision
2017-06-16 12:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-06-19 08:44
Articles in Press
2017-06-19 08:44
Publication Fee Transferred
2017-06-26 02:02
Edit the Manuscript by Language Editor
2017-07-04 11:40
Typeset the Manuscript
2017-09-06 12:59
Publish the Manuscript Online
2017-09-14 03:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Randomized Controlled Trial
Article Title P2Y1R is involved in visceral hypersensitivity in rats with experimental irritable bowel syndrome
Manuscript Source Unsolicited Manuscript
All Author List Jie Wu, Yan Cheng, Rong Zhang, Dong Liu, Yu-Mei Luo, Kun-Lun Chen, Song Ren and Jun Zhang
Funding Agency and Grant Number
Funding Agency Grant Number
MIMS (Shanghai) Ltd. of China IDF-2013-07
Correspondence To Dr. Jun Zhang, The Second Affiliated Hospital of School of Medicine, Xi’an Jiaotong University, No. 157 Xi Wu Road, Xi’an 710004, Shaanxi Province, China. junzh3z@163.com
Keywords Irritable bowel syndrome; P2Y1 receptor; regulation; therapy; visceral hypersensitivity
Core Tip P2Y1R is believed to be part of a high-sensitivity response to mechanical stimulation but whether it is involved in visceral hypersensitivity of irritable bowel syndrome is discussing. We detected its expression in the colon of a rat model of irritable bowel syndrome, and explored its regulatory role in visceral hypersensitivity with a specific agonist and an antagonist. The abdominal withdrawal reflex and electromyography tests showed effective changes after intervention. It was interesting to note that in case of combined treatment of the two drugs, the antagonist showed higher effects, which indicated that other P2 receptors might be involved in the hypersensitivity of irritable bowel syndrome.
Publish Date 2017-09-14 03:13
Citation Wu J, Cheng Y, Zhang R, Liu D, Luo YM, Chen KL, Ren S, Zhang J. P2Y1R is involved in visceral hypersensitivity in rats with experimental irritable bowel syndrome. World J Gastroenterol 2017; 23(34): 6339-6349
Url http://www.wjgnet.com/1007-9327/full/v23/i34/6339.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i34.6339
Full Article (PDF) WJG-23-6339.pdf
Full Article (Word) WJG-23-6339.doc
Revised Manuscript 34114-Review.doc
Peer-review Report 34114-Peer-review(s).pdf
Answering Reviewers 34114-Answering reviewers.pdf
Scientific Misconduct Check 34114-Scientific misconduct check.pdf
Scientific Editor Work List 34114-Scientific editor work list.pdf
Biostatistics Review Certificate 34114-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 34114-Conflict-of-interest statement.pdf
Copyright License Agreement 34114-Copyright assignment.pdf
Data Sharing Statement 34114-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 34114-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 34114-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 34114-Language certificate.pdf
Scientific Research Process 34114-Scientific research process.pdf