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9/28/2017 10:01:55 AM | Browse: 1654 | Download: 2492
Publication Name World Journal of Gastroenterology
Manuscript ID 34257
Country/Territory Brazil
Received
2017-04-17 12:22
Peer-Review Started
2017-04-27 17:39
To Make the First Decision
2017-06-05 00:27
Return for Revision
2017-06-11 10:25
Revised
2017-06-24 18:35
Second Decision
2017-08-07 05:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-08-15 15:21
Articles in Press
2017-08-15 15:21
Publication Fee Transferred
2017-08-25 16:39
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-09-22 01:56
Publish the Manuscript Online
2017-09-28 10:01
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Case Control Study
Article Title Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features
Manuscript Source Unsolicited Manuscript
All Author List Diego Marques, Layse Rayane Ferreira-Costa, Lorenna Larissa Ferreira-Costa, Romualdo da Silva Correa, Aline Maciel Pinheiro Borges, Fernanda Ribeiro Ito, Carlos Cesar de Oliveira Ramos, Raul Hernandes Bortolin, André Ducati Luchessi, Ândrea Ribeiro-dos-Santos, Sidney Santos and Vivian Nogueira Silbiger
ORCID
Author(s) ORCID Number
Diego Marques http://orcid.org/0000-0002-7446-6087
Layse Rayane Ferreira-Costa http://orcid.org/0000-0001-5870-9686
Lorenna Larissa Ferreira-Costa http://orcid.org/0000-0001-5629-4093
Romualdo da Silva Correa http://orcid.org/0000-0002-6255-6974
Aline Maciel Pinheiro Borges http://orcid.org/0000-0002-4342-7229
Fernanda Ribeiro Ito http://orcid.org/0000-0003-1569-5637
Carlos Cesar de Oliveira Ramos http://orcid.org/0000-0001-7581-8921
Raul Hernandes Bortolin http://orcid.org/0000-0003-3424-3281
André Ducati Luchessi http://orcid.org/0000-0002-2758-8102
Ândrea Ribeiro-dos-Santos http://orcid.org/0000-0001-7001-1483
Sidney Santos http://orcid.org/0000-0002-8622-9417
Vivian Nogueira Silbiger http://orcid.org/0000-0002-9252-0278
Funding Agency and Grant Number
Funding Agency Grant Number
Conselho Nacional de Desenvolvimento Científico e Tecnológico 483031/2013-5
Rede de Pesquisa em Genômica Populacional Humana Biocomputacional/CAPES-051/2013
Fundação de Amparo à Pesquisa do Estado do Pará 155/2014
Fundação de Amparo à Pesquisa do Estado do Rio Grande do Norte 005/2011
Corresponding Author Vivian Nogueira Silbiger, PhD, Professor, Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte, Av. General Gustavo Cordeiro de Faria S/N, Petrópolis, Natal 59012-570, Rio Grande do Norte, Brazil. viviansilbiger@hotmail.com
Key Words Colorectal cancer; Ins-del polymorphism; Admixed population; Potential biomarker; Diagnostic; Risk stratification; Prognostic; Clinical features
Core Tip The insertion-deletions (INDEL) variations in IL4 gene was associated with increased colorectal cancer (CRC) risk, while TYMS and UP2 genes were associated with decreased risk. The Del-alleles of NFKB1 and CASP8 were associated with more colon related incidents than rectosigmoid. The Ins-alleles of ACE, HLAG and TP53 were associated with higher TNM stage. The Ins-allele of ACE, HLAG, and UGT1A1 were associated with early relapse risk, as well as the Del-allele of TYMS. The Ins-alleles of SGSM3 and UGT1A1 were associated with death risk. These data suggest that these INDEL might be useful as a complementary tool for better CRC clinical management.
Publish Date 2017-09-28 10:01
Citation Marques D, Ferreira-Costa LR, Ferreira-Costa LL, Correa RS, Borges AMP, Ito FR, Ramos CCO, Bortolin RH, Luchessi AD, Ribeiro-dos-Santos A, Santos S, Silbiger VN. Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features. World J Gastroenterol 2017; 23(37): 6854-6867
URL http://www.wjgnet.com/1007-9327/full/v23/i37/6854.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i37.6854
Full Article (PDF) WJG-23-6854.pdf
Full Article (Word) WJG-23-6854.doc
Manuscript File 34257-Review.docx
Answering Reviewers 34257-Answering reviewers.pdf
Audio Core Tip 34257-Audio core tip.mp3
Biostatistics Review Certificate 34257-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 34257-Conflict-of-interest statement.pdf
Copyright License Agreement 34257-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 34257-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 34257-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 34257-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 34257-Language certificate.pdf
Supplementary Material 34257-Supplementary material.pdf
Peer-review Report 34257-Peer-review(s).pdf
Peer-review Report 34257-Scientific editor work list.pdf
Scientific Misconduct Check 34204-Scientific misconduct check.pdf