ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Oncology |
Manuscript Type |
Case Control Study |
Article Title |
Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features
|
Manuscript Source |
Unsolicited Manuscript |
All Author List |
Diego Marques, Layse Rayane Ferreira-Costa, Lorenna Larissa Ferreira-Costa, Romualdo da Silva Correa, Aline Maciel Pinheiro Borges, Fernanda Ribeiro Ito, Carlos Cesar de Oliveira Ramos, Raul Hernandes Bortolin, André Ducati Luchessi, Ândrea Ribeiro-dos-Santos, Sidney Santos and Vivian Nogueira Silbiger |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Conselho Nacional de Desenvolvimento Científico e Tecnológico |
483031/2013-5 |
Rede de Pesquisa em Genômica Populacional Humana |
Biocomputacional/CAPES-051/2013 |
Fundação de Amparo à Pesquisa do Estado do Pará |
155/2014 |
Fundação de Amparo à Pesquisa do Estado do Rio Grande do Norte |
005/2011 |
|
Corresponding Author |
Vivian Nogueira Silbiger, PhD, Professor, Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte, Av. General Gustavo Cordeiro de Faria S/N, Petrópolis, Natal 59012-570, Rio Grande do Norte, Brazil. viviansilbiger@hotmail.com |
Key Words |
Colorectal cancer; Ins-del polymorphism; Admixed population; Potential biomarker; Diagnostic; Risk stratification; Prognostic; Clinical features |
Core Tip |
The insertion-deletions (INDEL) variations in IL4 gene was associated with increased colorectal cancer (CRC) risk, while TYMS and UP2 genes were associated with decreased risk. The Del-alleles of NFKB1 and CASP8 were associated with more colon related incidents than rectosigmoid. The Ins-alleles of ACE, HLAG and TP53 were associated with higher TNM stage. The Ins-allele of ACE, HLAG, and UGT1A1 were associated with early relapse risk, as well as the Del-allele of TYMS. The Ins-alleles of SGSM3 and UGT1A1 were associated with death risk. These data suggest that these INDEL might be useful as a complementary tool for better CRC clinical management. |
Publish Date |
2017-09-28 10:01 |
Citation |
Marques D, Ferreira-Costa LR, Ferreira-Costa LL, Correa RS, Borges AMP, Ito FR, Ramos CCO, Bortolin RH, Luchessi AD, Ribeiro-dos-Santos A, Santos S, Silbiger VN. Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features. World J Gastroenterol 2017; 23(37): 6854-6867 |
URL |
http://www.wjgnet.com/1007-9327/full/v23/i37/6854.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v23.i37.6854 |