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7/25/2017 10:25:05 AM | Browse: 984 | Download: 1258
Publication Name World Journal of Hepatology
Manuscript ID 34300
Country/Territory Italy
Received
2017-04-12 09:08
Peer-Review Started
2017-04-12 18:18
To Make the First Decision
2017-05-22 04:03
Return for Revision
2017-05-23 09:19
Revised
2017-06-20 18:12
Second Decision
2017-06-22 02:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-07-03 02:40
Articles in Press
2017-07-03 02:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-07-16 13:20
Publish the Manuscript Online
2017-07-25 10:25
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Chemotherapy for hepatocellular carcinoma: The present and the future
Manuscript Source Invited Manuscript
All Author List Marco Le Grazie, Maria Rosa Biagini, Mirko Tarocchi, Simone Polvani and Andrea Galli
ORCID
Author(s) ORCID Number
Marco Le Grazie http://orcid.org/0000-0003-0832-4408
Maria Rosa Biagini http://orcid.org/0000-0003-4840-6731
Mirko Tarocchi http://orcid.org/0000-0002-7767-5116
Simone Polvani http://orcid.org/0000-0002-3707-1043
Andrea Galli http://orcid.org/0000-0001-5419-6290
Funding Agency and Grant Number
Corresponding Author Andrea Galli, MD, PhD, Gastroenterology Research Unit, Department of Experimental and Clinical Biochemical Sciences “Mario Serio, University of Florence, Viale Pieraccini 6, Florence 50139, Italy. a.galli@dfc.unifi.it
Key Words Hepatocellular carcinoma; Systemic therapy; Chemotherapy; Molecular targeted therapy; Cytotoxic therapy; Immunotherapy; Perspectives
Core Tip The aim of this review is to make a point on chemotherapeutic options for treatment of hepato­cellular carcinoma (HCC) at advanced stage, the most frequent stage of presentation of this neoplasia, still characterized by an important mortality rate. By now, sorafenib is the only standard treatment, but other options were recently studied and will be soon available for clinicians and patients affected by HCC. The review can be divided in four sections: The first one regards molecular target therapy and are described sorafenib, its open issues, but also other drugs with similar targets that have been evaluated for treatment of HCC. The second and the third parts regard cytotoxic drugs and immunotherapy, respectively, which were evaluated in recent years as possible alternatives or adjuvant to Sorafenib. In the last part of the review, future perspectives are described, in particular for what concerns resistance mechanism of the neoplasia, delivery methods or biological enhancers for drugs already in use, new drugs that will be probably evaluated and molecular targets that could soon become eligible for target therapy hopefully leading to the development of personalized therapy.
Publish Date 2017-07-25 10:25
Citation Le Grazie M, Biagini MR, Tarocchi M, Polvani S, Galli A. Chemotherapy for hepatocellular carcinoma: The present and the future. World J Hepatol 2017; 9(21): 907-920
URL http://www.wjgnet.com/1948-5182/full/v9/i21/907.htm
DOI http://dx.doi.org/10.4254/wjh.v9.i21.907
Full Article (PDF) WJH-9-907.pdf
Full Article (Word) WJH-9-907.doc
Manuscript File 34300-Review.doc
Answering Reviewers 34300_Response letter to reviewers.docx
Audio Core Tip 34300_audio core tip.mp3
Conflict-of-Interest Disclosure Form 34300_Conflict of interest statement.pdf
Copyright License Agreement 34300_Copyright assignment.pdf
Peer-review Report 34300-Peer-review(s).pdf
Scientific Misconduct Check 34300-Scientific misconduct check.pdf
Scientific Editor Work List 34300-Scientific editor work list.pdf