Publication Name	World Journal of Gastroenterology
Manuscript ID	34316
Country	China

Received	2017-04-15 12:42
Peer-Review Started	2017-04-17 21:22
To Make the First Decision	2017-05-12 09:26
Return for Revision	2017-05-16 09:04
Revised	2017-05-29 17:44
Second Decision	2017-07-05 23:53
Accepted by Journal Editor-in-Chief	2017-07-07 03:46
Accepted by Company Editor-in-Chief	2017-07-12 06:20
Articles in Press	2017-07-12 06:20
Publication Fee Transferred	2017-07-17 06:18
Edit the Manuscript by Language Editor	2017-07-26 21:53
Typeset the Manuscript	2017-08-18 00:17
Publish the Manuscript Online	2017-08-28 06:54

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Changes with aging in gastric biomarkers levels and in biochemical factors associated with Helicobacter pylori infection in asymptomatic Chinese population
Manuscript Source	Unsolicited Manuscript
All Author List	Jin-Hua Shan, Xiao-Juan Bai, Lu-Lu Han, Yuan Yuan and Xue-Feng Sun
ORCID	Author(s) ORCID Number Jin-Hua Shan http://orcid.org/0000-0002-1130-0784 Xiao-Juan Bai http://orcid.org/0000-0003-3890-8391 Lu-Lu Han http://orcid.org/0000-0002-8306-4506 Yuan Yuan http://orcid.org/0000-0002-9314-3371 Xue-Feng Sun http://orcid.org/0000-0002-6569-6737
Funding Agency and Grant Number	Funding Agency Grant Number the National Basic Research Program of China (973-Program) 2007CB507405 the National Basic Research Program of China (973-Program) 2013CB530803 the National Basic Research Program of China (973-Program) 2013CB530804
Corresponding Author	Xiao-Juan Bai, Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China. baixj@sj-hospital.org
Key Words	Helicobacter pylori antibody; Pepsinogen; Gastrin; Gastric ageing
Core Tip	Our study showed that in an entire healthy population, levels of serum pepsinogen (PG) Ⅱ in­creased while PGⅠ/PGⅡ declined with age. We dis­covered that Helicobacter pylori (H. pylori) infection had an effect on raising levels of low-density lipoprotein cholesterol to increase the risk of atherosclerosis in males, especially those who are elderly. We also found that age, H. pylori infection, serum levels of renal function indicators and fasting blood glucose (FBG) were associated with levels of serum PGs and gastrin; it was assumed that they may influence the secretory function of gastric mucosa and that abnormal serum levels of FBG and renal function might participate in the occurrence and development of gastric diseases.
Publish Date	2017-08-28 06:54
Citation	Shan JH, Bai XJ, Han LL, Yuan Y, Sun XF. Changes with aging in gastric biomarkers levels and in biochemical factors associated with Helicobacter pylori infection in asymptomatic Chinese population. World J Gastroenterol 2017; 23(32): 5945-5953
URL	http://www.wjgnet.com/1007-9327/full/v23/i32/5945.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i32.5945

Full Article (PDF)	WJG-23-5945.pdf
Full Article (Word)	WJG-23-5945.doc
Manuscript File	34316-Review.doc
Answering Reviewers	34316-Answering reviewers.pdf
Audio Core Tip	34316-Audio core tip.wav
Biostatistics Review Certificate	34316-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	34316-Conflict-of-interest statement.pdf
Copyright License Agreement	34316-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	34316-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	34316-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	34316-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	34316-Language certificate.pdf
Supplementary Material	34316_34316-Ethic approval document.pdf
Peer-review Report	34316-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	34316-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	34316-Scientific misconduct check.pdf
Scientific Editor Work List	34316-Scientific editor work list.pdf