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11/3/2017 6:13:02 AM | Browse: 984 | Download: 1418
Publication Name World Journal of Virology
Manuscript ID 34848
Country/Territory United States
Received
2017-06-12 01:14
Peer-Review Started
2017-06-12 01:32
To Make the First Decision
2017-07-10 00:47
Return for Revision
2017-07-20 02:59
Revised
2017-08-03 22:53
Second Decision
2017-09-07 05:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-09-17 04:12
Articles in Press
2017-09-17 04:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-10-31 03:57
Publish the Manuscript Online
2017-11-03 06:13
ISSN 2220-3249 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Observational Study
Article Title Real-world cure rates for hepatitis C virus treatments that include simeprevir and/or sofosbuvir are comparable to clinical trial results
Manuscript Source Invited Manuscript
All Author List Kian Bichoupan, Neeta Tandon, James F Crismale, Joshua Hartman, David Del Bello, Neal Patel, Sweta Chekuri, Alyson Harty, Michel Ng, Keith M Sigel, Meena B Bansal, Priya Grewal, Charissa Y Chang, Jennifer Leong, Gene Y Im, Lawrence U Liu, Joseph A Odin, Nancy Bach, Scott L Friedman, Thomas D Schiano, Ponni V Perumalswami, Douglas T Dieterich and Andrea D Branch
ORCID
Author(s) ORCID Number
Kian Bichoupan http://orcid.org/0000-0002-4449-7229
Neeta Tandon http://orcid.org/0000-0002-9474-7214
James F Crismale http://orcid.org/0000-0002-3219-882X
Joshua Hartman http://orcid.org/0000-0002-4169-4825
David Del Bello http://orcid.org/0000-0002-3248-0235
Neal Patel http://orcid.org/0000-0002-9004-6883
Sweta Chekuri http://orcid.org/0000-0003-2123-1951
Alyson Harty http://orcid.org/0000-0002-8979-4905
Michel Ng http://orcid.org/0000-0002-6555-9337
Keith M Sigel http://orcid.org/0000-0002-4051-4861
Meena B Bansal http://orcid.org/0000-0002-7501-2191
Priya Grewal http://orcid.org/0000-0001-7820-9769
Charissa Y Chang http://orcid.org/0000-0002-1814-5131
Jennifer Leong http://orcid.org/0000-0003-2386-4437
Gene Y Im http://orcid.org/0000-0003-0009-8418
Lawrence U Liu http://orcid.org/0000-0001-8847-841X
Joseph A Odin http://orcid.org/0000-0003-0923-5685
Nancy Bach http://orcid.org/0000-0003-2939-0391
Scott L Friedman http://orcid.org/0000-0003-1178-6195
Thomas D Schiano http://orcid.org/0000-0003-1878-5101
Ponni V Perumalswami http://orcid.org/0000-0003-3070-3906
Douglas T Dieterich http://orcid.org/0000-0001-7786-8594
Andrea D Branch http://orcid.org/0000-0003-2865-3188
Funding Agency and Grant Number
Funding Agency Grant Number
NIDDK DK090317
NIDA DA031095
Corresponding Author Andrea D Branch, PhD, Professor, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, United States. andrea.branch@mssm.edu
Key Words Cirrhosis; Cost; Sustained virological response; Protease inhibitor; Polymerase inhibitor
Core Tip To our knowledge, this study is the largest real-world investigation of outcomes in patients with chronic hepatitis C virus infection with genotypes 1-4 being treated with simeprevir and/or sofosbuvir-containing regimens that has been conducted in a single center. We provide compelling real-world data in a large (n = 508), diverse population of patients, showing that the effectiveness of these regimens is comparable to that seen in multicenter clinical trials. Further, our unique cost analysis reveals that the cost-per-sustained virological response of simeprevir- and/or sofosbuvir-based therapy is lower than telaprevir-based triple therapy, likely due to higher rates of cure and lower rates of adverse events.
Publish Date 2017-11-03 06:13
Citation Bichoupan K, Tandon N, Crismale JF, Hartman J, Del Bello D, Patel N, Chekuri S, Harty A, Ng M, Sigel KM, Bansal MB, Grewal P, Chang CY, Leong J, Im GY, Liu LU, Odin JA, Bach N, Friedman SL, Schiano TD, Perumalswami PV, Dieterich DT, Branch AD. Real-world cure rates for hepatitis C virus treatments that include simeprevir and/or sofosbuvir are comparable to clinical trial results. World J Virol 2017; 6(4): 59-72
URL http://www.wjgnet.com/2220-3249/full/v6/i4/59.htm
DOI http://dx.doi.org/10.5501/wjv.v6.i4.59
Full Article (PDF) WJV-6-59.pdf
Full Article (Word) WJV-6-59.doc
Manuscript File 34848-Review.docx
Answering Reviewers 34848-Answering reviewers.pdf
Audio Core Tip 34848-Audio-revision.m4a
Biostatistics Review Certificate 34848-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 34848-Conflict-of-interest statement.pdf
Copyright License Agreement 34848-Copyright assignment.pdf
Data Sharing Statement 34848-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 34848-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 34848-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 34848-Institutional review board statement.pdf
Scientific Research Process 34848-Scientific research process.pdf
Supplementary Material 34848-Supplementary material.pdf
Peer-review Report 34848-Peer-review(s).pdf
Scientific Misconduct Check 34848-Scientific misconduct check.pdf
Scientific Editor Work List 34848-Scientific editor work list.pdf