| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Eva Dolezelova, Alena Prasnicka, Jolana Cermanova, Alejandro Carazo, Lucie Hyrsova, Miloš Hroch, Jaroslav Mokry, Michaela Adamcova, Alena Mrkvicova, Petr Pavek and Stanislav Micuda |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grant Agency of Charles University |
Progres Q40/05 |
| Specific University Research |
SVV-2016-260287 |
| Czech Science Foundation (GA CR) |
303/12/G163 |
|
| Corresponding Author |
Stanislav Micuda, MD, PhD, Professor, Department of Pharmacology, Charles University, Faculty of Medicine in Hradec Kralove, Simkova 870, Hradec Kralove 50003, Czech Republic. micuda@lfhk.cuni.cz |
| Key Words |
Resveratrol; Bile production; Bile acids; Pregnane X receptor; Azithromycin |
| Core Tip |
For the first time, our results provide information about the ability of resveratrol to increase bile flow in healthy rats by increasing the biliary excretion of bile acids and glutathione via posttranscriptional induction of their rate-limiting transporters, Bsep and Mrp2, respectively, and via the up-regulation of Cyp7a1, an enzyme that is crucial for bile acid synthesis. Resveratrol simultaneously induced hepatic expression of Mdr1, which was verified by increased biliary excretion of its substrate, azithromycin. Our findings were consistent with an agonistic effect of resveratrol on PXR. Our data therefore imply that oral administration of resveratrol may modify the kinetics of endo- and xenobiotics. |
| Publish Date |
2017-11-20 04:03 |
| Citation |
Dolezelova E, Prasnicka A, Cermanova J, Carazo A, Hyrsova L, Hroch M, Mokry J, Adamcova M, Mrkvicova A, Pavek P, Micuda S. Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats. World J Gastroenterol 2017; 23(43): 7678-7692 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i43/7678.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i43.7678 |
