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Articles Published Processes
11/5/2017 12:48:27 AM | Browse: 672 | Download: 687
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Received |
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2017-07-21 00:21 |
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Peer-Review Started |
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2017-07-21 02:48 |
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To Make the First Decision |
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2017-08-10 00:34 |
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Return for Revision |
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2017-08-10 06:25 |
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Revised |
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2017-08-22 08:22 |
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Second Decision |
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2017-09-06 23:58 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2017-09-13 03:01 |
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Articles in Press |
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2017-09-13 03:01 |
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Publication Fee Transferred |
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2017-09-29 03:56 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-10-23 07:43 |
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Publish the Manuscript Online |
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2017-11-05 00:48 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Reabsorption of iron into acutely damaged rat liver: A role for ferritins
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ihtzaz Ahmed Malik, Jörg Wilting, Giuliano Ramadori and Naila Naz |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ihtzaz Ahmed Malik, PhD, Doctor, Institute of Anatomy and Cell Biology, University Medical Center Goettingen, Kreuzbergring 36, Goettingen D-37075, Deutschland, Germany. i.malik@med.uni-goettingen.de |
| Key Words |
Iron metabolism, Ferritin, Liver, Cytokines, Acute liver damage |
| Core Tip |
In humans, an increase in hepatic iron concentration is caused by chronic hepatitis-C infection, alcohol abuse, and non-alcoholic fatty liver disease. The pathophysiology behind increased liver iron concentrations caused by acute liver damage has remained obscure. Using thioacetamide-injection in rats, we demonstrate that the increase in liver iron may be a consequence rather than the cause of hepatocyte damage. Thereby, iron is released into serum by damaged hepatocytes during acute liver damage, and reabsorbed by remaining hepatocytes (but not spleen) by means of ferritin L and ferritin H subunits. Our studies also show that ferritin H is a promising surrogate marker for damaged hepatocytes. |
| Publish Date |
2017-11-05 00:48 |
| Citation |
Malik IA, Wilting J, Ramadori G, Naz N. Reabsorption of iron into acutely damaged rat liver: A role for ferritins. World J Gastroenterol 2017; 23(41): 7347-7358 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i41/7347.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i41.7347 |
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