| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Potential rat model of anxiety-like gastric hypersensitivity induced by sequential stress
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fu-Chun Jing, Jun Zhang, Chen Feng, Yuan-Yuan Nian, Jin-Hai Wang, Hao Hu, Bao-De Yang, Xiao-Ming Sun, Jian-Yun Zheng and Xiao-Ran Yin |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jun Zhang, PhD, Chief Doctor, Professor, Department of Gastroenterology, Second Hospital Affiliated to the Medical School of Xi’an Jiao Tong University, No. 157, West Road 5, Xi’an 710004, Shaanxi Province, China. jun3z@163.com |
| Key Words |
Gastric hypersensitivity; Anxiety; Functional dyspepsia; 5-Hydroxytryptamine; γ-aminobutyric acid; Brain-derived neurotrophic factor; Nesfatin-1; Rat model |
| Core Tip |
Functional dyspepsia (FD) is a common gastrointestinal disorder in clinic. Gastric hypersensitivity (GHS) and anxiety are important factors triggering or aggravating it, however, the mechanisms by which affect the development of FD are still unknown. In part, this is due to a lack of suitable animal models of FD with anxiety and GHS. Our study provided such a newly developed rat model induced by sequential stress. It demonstrated the complex behavioral characteristics of anxiety and GHS, and the complicated alterations in some anxiety-related neurobiochemical modulators such as 5-HT, GABA, BDNF and nesfatin-1 in the hippocampus, plasma and gastric fundus. |
| Publish Date |
2017-11-12 06:39 |
| Citation |
Jing FC, Zhang J, Feng C, Nian YY, Wang JH, Hu H, Yang BD, Sun XM, Zheng JY, Yin XR. Potential rat model of anxiety-like gastric hypersensitivity induced by sequential stress. World J Gastroenterol 2017; 23(42): 7594-7608 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i42/7594.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i42.7594 |
