ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Transplantation |
Manuscript Type |
Retrospective Cohort Study |
Article Title |
Pretransplantation fetal-maternal microchimerism in pediatric liver transplantation from mother
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Nam-Joon Yi, Min-Su Park, Eun Young Song, Hye Young Ahn, Jeik Byun, Hyeyoung Kim, Suk Kyun Hong, Kyungchul Yoon, Hyo-Sin Kim, Sung-Woo Ahn, Hae Won Lee, YoungRok Choi, Kwang-Woong Lee, Kyung-Suk Suh and Myoung Hee Park |
ORCID |
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Funding Agency and Grant Number |
Funding Agency |
Grant Number |
the Korean Society for Transplantation |
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Corresponding Author |
Myoung Hee Park, MD, PhD, Korea Organ Donation Agency Laboratory, 6F, 12, Nonhyeon-ro 132-gil, Gangnam-g, Seoul 06052, South Korea. parkmhee@snu.ac.kr |
Key Words |
Liver transplantation; Microchimerism; Maternal graft; Graft survival; Non-inherited maternal antigen; Biopsy-proven cellular rejection |
Core Tip |
We firstly investigated the rates of pretransplantation microchimerism (MC) to non-inherited maternal antigens (NIMAs) (NIMA-MC) in pediatric liver transplantation (LT) patients and its effect on biopsy-proven cellular rejection (BPCR) in those receiving maternal grafts. NIMA-MC for HLA-DRB1 alleles was successfully evaluated in 26 of the 45 children, and pretransplantation NIMA-MC was detected in 23.1% of the patients. Our study demonstrated that none of the patients with NIMA-MC positivity or HLA-DR identity with the mother developed BPCR. The presence of pretransplantation NIMA-MC or HLA-DR identity with the mother could be associated with BPCR-free survival in pediatric LT recipients from maternal donors. |
Publish Date |
2017-12-04 08:09 |
Citation |
Yi NJ, Park MS, Song EY, Ahn HY, Byun J, Kim H, Hong SK, Yoon K, Kim HS, Ahn SW, Lee HW, Choi Y, Lee KW, Suh KS, Park MH. Pretransplantation fetal-maternal microchimerism in pediatric liver transplantation from mother. World J Gastroenterol 2017; 23(45): 8017-8026 |
URL |
http://www.wjgnet.com/1007-9327/full/v23/i45/8017.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v23.i45.8017 |