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9/14/2017 3:13:08 AM | Browse: 124 | Download: 52
Publication Name World Journal of Gastroenterology
Manuscript ID 35634
Country of Manuscript Source United States
2017-07-28 02:21
Peer-Review Started
2017-07-28 02:46
To Make the First Decision
2017-08-10 00:28
Return for Revision
2017-08-14 13:24
2017-08-16 21:53
Second Decision
2017-08-30 00:48
Accepted by Journal Editor-in-Chief
2017-08-30 22:30
Accepted by Company Editor-in-Chief
2017-09-05 18:25
Articles in Press
2017-09-05 18:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-09-07 05:45
Publish the Manuscript Online
2017-09-14 03:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Editorial
Article Title Defining and predicting deep remission in patients with perianal fistulizing Crohn’s disease on anti-tumor necrosis factor therapy
Manuscript Source Invited Manuscript
All Author List Konstantinos Papamichail and Adam S Cheifetz
Author ORCID Number
Konstantinos Papamichail http://orcid.org/0000-0003-1497-0254
Adam S Cheifetz http://orcid.org/0000-0002-6010-1896
Funding Agency and Grant Number
Correspondence To Konstantinos Papamichail, FEBG, MD, PhD, Center for Inflammatory Bowel Diseases, Division of Gastroenterology, Beth-Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave., Boston, Brookline, MA02215, United States. kpapamic@bidmc.harvard.edu
Keywords Inflammatory bowel disease; Infliximab; Adalimumab; magnetic resonance imaging; Drug monitoring; Fistula healing
Core Tip Defining and predicting deep remission is important to guide the management of patients with perianal fistulizing Crohn’s disease (CD). Deep remission, defined as complete fistula healing based on objective endoscopic and radiologic findings, should be the goal of care in the treatment of patients with perianal CD. Currently, anti-tumor necrosis factor (anti-TNF) are the standard of care for perianal CD, but long-term outcomes are disappointing. Data suggests that higher infliximab concentrations are associated with better clinical outcomes in patients with perianal fistulising CD and thus therapeutic drug monitoring may be a valid therapeutic strategy for optimizing anti-TNF therapy towards improved objective outcomes and deep remission.
Publish Date 2017-09-14 03:13
Citation Papamichael K, Cheifetz AS. Defining and predicting deep remission in patients with perianal fistulizing Crohn’s disease on anti-tumor necrosis factor therapy. World J Gastroenterol 2017; 23(34): 6197-6200
Url http://www.wjgnet.com/1007-9327/full/v23/i34/6197.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i34.6197
Full Article (PDF) WJG-23-6197.pdf
Full Article (Word) WJG-23-6197.doc
Revised Manuscript 35634-Review.doc
Peer-review Report 35634-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 35634-Journal editor-in-chief review report.pdf
Answering Reviewers 35634-Answering reviewers.pdf
Scientific Misconduct Check 35634-Scientific misconduct check.pdf
Scientific Editor Work List 35634-Scientific editor work list.pdf
Audio Core Tip 35634-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 35634-Conflict-of-interest statement.pdf
Copyright License Agreement 35634-Copyright assignment.pdf