ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Mitofusin-2 mediated mitochondrial Ca2+ uptake 1/2 induced liver injury in rat remote ischemic perconditioning liver transplantation and alpha mouse liver-12 hypoxia cell line models
|
Manuscript Source |
Unsolicited Manuscript |
All Author List |
Ruo-Peng Liang, Jun-Jun Jia, Jian-Hui Li, Ning He, Yan-Fei Zhou, Li Jiang, Tao Bai, Hai-Yang Xie, Lin Zhou and Yu-Ling Sun |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Science and Technology Innovation Talents Support Plan, Department of Education, Henan Province, China |
No. 17HASTIT044 |
China Postdoctoral Science Foundation |
No. 2017M610374 |
|
Corresponding Author |
Yu-Ling Sun, MD, PhD, Professor, Surgeon, Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhengzhou University, 1st Jianshe East Road, Zhengzhou, Zhengzhou 450052, Henan, China. ylsun@zzu.edu.cn |
Key Words |
Remote ischemic per-conditioning; Ischemia reperfusion injury; Ca2+; Mitofusin-2; Mitochondrial Ca2+ uniporter |
Core Tip |
Compared to the orthotopic liver transplantation, remote ischemic preconditioning (RIC) model can significantly improve liver functions. But knowledge of its mechanism remains largely unknown. This research is the first to prove the protective mechanism of mitofusin-2-mitochondrial Ca2+ uptake 1/2 axis by affecting the metabolism of intracellular calcium in RIC model of liver transplantation and revalidate it in alpha mouse liver-12 hypoxia cell lines. |
Publish Date |
2017-10-16 07:24 |
Citation |
Liang RP, Jia JJ, Li JH, He N, Zhou YF, Jiang L, Bai T, Xie HY, Zhou L, Sun YL. Mitofusin-2 mediated mitochondrial Ca2+ uptake 1/2 induced liver injury in rat remote ischemic perconditioning liver transplantation and alpha mouse liver-12 hypoxia cell line models. World J Gastroenterol 2017; 23(38): 6995-7008 |
URL |
http://www.wjgnet.com/1007-9327/full/v23/i38/6995 |
DOI |
http://dx.doi.org/10.3748/wjg.v23.i38.6995 |