Publication Name	World Journal of Cardiology
Manuscript ID	3585
Country	Italy

Received	2013-05-08 07:58
Peer-Review Started	2013-05-08 09:53
To Make the First Decision	2013-07-19 08:51
Return for Revision	2013-07-22 16:10
Revised	2013-07-31 22:17
Second Decision	2013-09-13 14:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-09-13 22:44
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-23 18:51
Publish the Manuscript Online	2013-10-24 17:56

ISSN	1949-8462 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Autobiography
Article Title	Migraine attack restores the response of vascular smooth muscle cells to nitric oxide but not to norepinephrine
Manuscript Source	Invited Manuscript
All Author List	Raffaele Napoli, Vincenzo Guardasole, Emanuela Zarra, Antonietta De Sena, Francesco Saccà, Antonio Ruvolo, Simona Grassi, Speranza Giugliano, Giovanna De Michele, Antonio Cittadini, Pietro Biagio Carrieri and Luigi Saccà
Funding Agency and Grant Number
Corresponding Author	Raffaele Napoli, MD, Department of Translational Medical Sciences, Federico Ⅱ University School of Medicine, Via Pansini 5, 80131 Napoli, Italy. napoli@unina.it
Key Words	Migraine; Nitric oxide; Endothelium; Vascular smooth muscle cells
Core Tip	Patients with migraine without aura studied in the interictal period are characterized by impaired ability of vascular smooth muscle cells (VSMCs) to relax in response to nitric oxide and to contract in response to norepinephrine. We hypothesize that the two defects compensate for each other and this provides for the maintenance of normal vascular resistance and blood pressure homeostasis. In contrast, during the headache attack, the VSMCs regain their ability to respond to nitric oxide, but remain unresponsive to norepinephrine. Such differential effect of the migraine attack is not surprising, given that nitric oxide and norepinephrine activate different intracellular signaling pathways in VSMCs.
Publish Date	2013-10-24 17:56
Citation	Napoli R, Guardasole V, Zarra E, De Sena A, Saccà F, Ruvolo A, Grassi S, Giugliano S, De Michele G, Cittadini A, Carrieri PB, Saccà L. Migraine attack restores the response of vascular smooth muscle cells to nitric oxide but not to norepinephrine. World J Cardiol 2013; 5(10): 375-381
URL	http://www.wjgnet.com/1949-8462/full/v5/i10/375.htm
DOI	http://dx.doi.org/10.4330/wjc.v5.i10.375

Full Article (PDF)	WJC-5-375.pdf
Manuscript File	3585-Review.doc
Answering Reviewers	3585-Answering reviewers.pdf
Copyright License Agreement	3585-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3585-Language certificate.docx
Peer-review Report	3585-Peer reviewer(s).pdf
Scientific Editor Work List	3585-Scientific editor work list.doc