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11/12/2017 6:39:43 AM | Browse: 1037 | Download: 1408
Publication Name World Journal of Gastroenterology
Manuscript ID 35945
Country/Territory China
Received
2017-08-22 00:38
Peer-Review Started
2017-08-24 06:52
To Make the First Decision
2017-09-13 00:49
Return for Revision
2017-09-13 02:43
Revised
2017-09-17 05:33
Second Decision
2017-10-17 07:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-10-17 20:08
Articles in Press
2017-10-17 20:08
Publication Fee Transferred
2017-10-23 05:50
Edit the Manuscript by Language Editor
2017-10-27 13:43
Typeset the Manuscript
2017-11-06 04:36
Publish the Manuscript Online
2017-11-12 06:39
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Novel D-galactosamine-induced cynomolgus monkey model of acute liver failure
Manuscript Source Unsolicited Manuscript
All Author List Lei Feng, Lei Cai, Guo-Lin He, Jun Weng, Yang Li, Ming-Xin Pan, Ze-Sheng Jiang, Qing Peng and Yi Gao
ORCID
Author(s) ORCID Number
Lei Feng http://orcid.org/0000-0001-6053-8417
Lei Cai http://orcid.org/0000-0003-1658-7996
Guo-Lin He http://orcid.org/0000-0001-8032-1434
Jun Weng http://orcid.org/0000-0003-0792-1526
Yang Li http://orcid.org/0000-0003-4718-1825
Ming-Xin Pan http://orcid.org/0000-0002-3979-5571
Ze-Sheng Jiang http://orcid.org/0000-0002-2170-2031
Qing Peng http://orcid.org/0000-0002-7790-6455
Yi Gao http://orcid.org/0000-0003-3525-0133
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81470875
Natural Science Foundation of Guangdong Province, China 2014A030312013
Science and Technology Planning Project of Guangdong Province, China 2014B020227002
Science and Technology Planning Project of Guangdong Province, China 2015B090903069
Science and Technology Planning Project of Guangdong Province, China 2015B020229002
Science and Technology Program of Guangzhou, China 201604020002
Corresponding Author Yi Gao, MD, Professor, Surgeon, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine,State Key Laboratory of Organ Failure Research, Zhujiang Hospital, Southern Medical University, Number 253 Industry Road, Hai Zhu District, Guangzhou 510282, Guangdong Province, China. drgaoy@126.com
Key Words Cynomolgus monkey; D-galactosamine; Acute liver failure; Artificial liver support systems; Intracranial pressure
Core Tip This is an article about a novel D-galactosamine-induced cynomolgus monkey model of ALF. In this study, we used small saphenous vein puncture instead of jugular vein intubation for different doses of D-gal administration, which not only effectively avoided the trauma caused by intubation, but also significantly reduced the anesthesia time and greatly improved the convenience of operation. This study concluded that a simplified, reproducible, D-gal-induced, large-animal ALF model with an appropriate treatment window had been established successfully, which is suitable to further assess the safety and efficacy of ALSS or to studying the pathogenesis of ALF and developing new drugs.
Publish Date 2017-11-12 06:39
Citation Feng L, Cai L, He GL, Weng J, Li Y, Pan MX, Jiang ZS, Peng Q, Gao Y. Novel D-galactosamine-induced cynomolgus monkey model of acute liver failure. World J Gastroenterol 2017; 23(42): 7572-7583
URL http://www.wjgnet.com/1007-9327/full/v23/i42/7572.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i42.7572
Full Article (PDF) WJG-23-7572.pdf
Full Article (Word) WJG-23-7572.doc
Manuscript File 35945-Review.docx
Answering Reviewers 35945-Answering reviewers.pdf
Audio Core Tip 35945-Audio core tip.mp3
Biostatistics Review Certificate 35945-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 35945-Conflict-of-interest statement.pdf
Copyright License Agreement 35945-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 35945-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 35945-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 35945-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 35945-Language certificate.pdf
Supplementary Material 35945-Supplementary Material.docx
Peer-review Report 35945-Peer-review(s).pdf
Scientific Misconduct Check 35945-Scientific misconduct check.pdf
Scientific Editor Work List 35945-Scientific editor work list.pdf