ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Permissions |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Novel D-galactosamine-induced cynomolgus monkey model of acute liver failure
|
Manuscript Source |
Unsolicited Manuscript |
All Author List |
Lei Feng, Lei Cai, Guo-Lin He, Jun Weng, Yang Li, Ming-Xin Pan, Ze-Sheng Jiang, Qing Peng and Yi Gao |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundation of China |
81470875 |
Natural Science Foundation of Guangdong Province, China |
2014A030312013 |
Science and Technology Planning Project of Guangdong Province, China |
2014B020227002 |
Science and Technology Planning Project of Guangdong Province, China |
2015B090903069 |
Science and Technology Planning Project of Guangdong Province, China |
2015B020229002 |
Science and Technology Program of Guangzhou, China |
201604020002 |
|
Corresponding Author |
Yi Gao, MD, Professor, Surgeon, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine,State Key Laboratory of Organ Failure Research, Zhujiang Hospital, Southern Medical University, Number 253 Industry Road, Hai Zhu District, Guangzhou 510282, Guangdong Province, China. drgaoy@126.com |
Key Words |
Cynomolgus monkey; D-galactosamine; Acute liver failure; Artificial liver support systems; Intracranial pressure |
Core Tip |
This is an article about a novel D-galactosamine-induced cynomolgus monkey model of ALF. In this study, we used small saphenous vein puncture instead of jugular vein intubation for different doses of D-gal administration, which not only effectively avoided the trauma caused by intubation, but also significantly reduced the anesthesia time and greatly improved the convenience of operation. This study concluded that a simplified, reproducible, D-gal-induced, large-animal ALF model with an appropriate treatment window had been established successfully, which is suitable to further assess the safety and efficacy of ALSS or to studying the pathogenesis of ALF and developing new drugs. |
Publish Date |
2017-11-12 06:39 |
Citation |
Feng L, Cai L, He GL, Weng J, Li Y, Pan MX, Jiang ZS, Peng Q, Gao Y. Novel D-galactosamine-induced cynomolgus monkey model of acute liver failure. World J Gastroenterol 2017; 23(42): 7572-7583 |
URL |
http://www.wjgnet.com/1007-9327/full/v23/i42/7572.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v23.i42.7572 |