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Publication Name World Journal of Gastroenterology
Manuscript ID 36089
Country/Territory Spain
2017-08-30 03:25
Peer-Review Started
2017-09-28 08:44
To Make the First Decision
2017-10-18 06:50
Return for Revision
2017-10-19 08:46
2017-12-25 00:33
Second Decision
2018-01-18 10:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-01-18 15:11
Articles in Press
2018-01-18 15:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-01-31 10:05
Publish the Manuscript Online
2018-02-06 03:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Analysis of hepatitis B virus preS1 variability and prevalence of the rs2296651 polymorphism in a Spanish population
Manuscript Source Invited Manuscript
All Author List Rosario Casillas, David Tabernero, Josep Gregori, Irene Belmonte, Maria Francesca Cortese, Carolina González, Mar Riveiro-Barciela, Rosa Maria López, Josep Quer, Rafael Esteban, Maria Buti and Francisco Rodriguez-Frias
Author(s) ORCID Number
Rosario Casillas http://orcid.org/0000-0002-6758-6734
David Tabernero http://orcid.org/0000-0002-1146-4084
Josep Gregori http://orcid.org/0000-0002-4253-8015
Irene Belmonte http://orcid.org/0000-0002-8675-8343
Maria Francesca Cortese http://orcid.org/0000-0002-4318-532X
Carolina González http://orcid.org/0000-0002-0169-5874
Mar Riveiro-Barciela http://orcid.org/0000-0001-9309-2052
Rosa Maria López http://orcid.org/0000-0001-6207-7669
Josep Quer http://orcid.org/0000-0003-0014-084X
Rafael Esteban http://orcid.org/0000-0001-5280-392X
Maria Buti http://orcid.org/0000-0002-0732-3078
Francisco Rodriguez-Frias http://orcid.org/0000-0001-9058-4641
Funding Agency and Grant Number
Funding Agency Grant Number
Instituto de Salud Carlos II, cofinanced by the European Regional Development Fund (ERDF) PI14/01416
Instituto de Salud Carlos II, cofinanced by the European Regional Development Fund (ERDF) PI15/00856
Gilead Fellowship Program GLD14-00296
Corresponding Author David Tabernero, PhD, Postdoc, Research Scientist, Liver Pathology Unit, Departments of Biochemistry and Microbiology, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Passeig Vall d’Hebron 119-129, clinical laboratories, office 212, Barcelona 08035, Spain. david.tabernero@ciberehd.org
Key Words Hepatitis B virus; Hepatitis B virus preS1 region; Sodium-taurocholate co-transporting polypeptide; NTCP-interacting domain; Virion morphogenesis domain; SNP rs2296651; Next-generation sequencing; Real-time PCR melting curves
Core Tip Simultaneous analysis of both viral and host features important for hepatitis B virus (HBV) entry into hepatocytes provided locally relevant preliminary information in a population previously uncharacterized in this regard. In-house developed next-generation sequencing was successfully used to investigate the variability of the preS1 domain of the HBV large envelope protein, and real-time PCR melting curve analysis to detect the rs2296651 polymorphism (NTCP variant, S267F) in the HBV cellular receptor, NTCP. Results in a limited sample indicate that the features analyzed would not decrease the effectiveness of new therapies to block NTCP and avert HBV binding to hepatocytes in our particular CHB population.
Publish Date 2018-02-06 03:22
Citation Casillas R, Tabernero D, Gregori J, Belmonte I, Cortese MF, González C, Riveiro-Barciela M, López RM, Quer J, Esteban R, Buti M, Rodríguez-Frías F. Analysis of hepatitis B virus preS1 variability and prevalence of the rs2296651 polymorphism in a Spanish population. World J Gastroenterol 2018; 24(6): 680-692
URL http://www.wjgnet.com/1007-9327/full/v24/i6/680.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i6.680
Full Article (PDF) WJG-24-680.pdf
Full Article (Word) WJG-24-680.doc
Manuscript File 36089-Review.docx
Answering Reviewers 36089-Answering reviewers.pdf
Audio Core Tip 36089-Audio core tip.mp3
Biostatistics Review Certificate 36089-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 36089-Conflict-of-interest statement.pdf
Copyright License Agreement 36089-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 36089-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 36089-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 36089-Language certificate.pdf
Supplementary Material 36089-Supplementary material.pdf
Peer-review Report 36089-Peer-review(s).pdf
Scientific Misconduct Check 36089-Scientific misconduct check.pdf
Scientific Editor Work List 36089-Supplementary material.pdf