Publication Name	World Journal of Hepatology
Manuscript ID	36309
Country	Denmark

Received	2017-10-13 02:54
Peer-Review Started	2017-10-13 07:45
To Make the First Decision	2017-11-07 06:01
Return for Revision	2017-11-07 06:32
Revised	2017-11-20 22:50
Second Decision	2017-11-28 08:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-12-06 21:23
Articles in Press	2017-12-06 21:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-01-21 02:14
Publish the Manuscript Online	2018-01-26 08:09

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Preserved liver regeneration capacity after partial hepatectomy in rats with non-alcoholic steatohepatitis
Manuscript Source	Unsolicited Manuscript
All Author List	David Haldrup, Sara Heebøll, Karen Louise Thomsen, Kasper Jarlhelt Andersen, Michelle Meier, Frank Viborg Mortensen, Jens Randel Nyengaard, Stephen Hamilton-Dutoit and Henning Grønbæk
ORCID	Author(s) ORCID Number David Haldrup http://orcid.org/0000-0003-0023-8564 Sara Heebøll http://orcid.org/0000-0002-3474-0379 Karen Louise Thomsen http://orcid.org/0000-0002-8118-4643 Kasper Jarlhelt Andersen http://orcid.org/0000-0002-5290-7515 Michelle Meier http://orcid.org/0000-0002-8515-5401 Frank Viborg Mortensen http://orcid.org/0000-0001-7580-8037 Jens Randel Nyengaard http://orcid.org/0000-0002-8084-4646 Stephen Hamilton-Dutoit http://orcid.org/0000-0003-2158-3885 Henning Grønbæk http://orcid.org/0000-0001-8998-7910
Funding Agency and Grant Number
Corresponding Author	David Haldrup, MD, Doctor, Department of Gastroenterology and Hepatology, Aarhus University Hospital, Nørrebrogade 44, Aarhus C DK-8000, Denmark. davihald@rm.dk
Key Words	Rat; Non-alcoholic fatty liver; Non-alcoholic steatohepatitis; Liver regeneration; Hepatectomy; Ki-67; Gene expression
Core Tip	Liver regeneration capacity has been studied in different animal models of non-alcoholic steatohepatitis. This study is the first to use a high fat high cholesterol model which mimic the pathogenesis of human non-alcoholic steatohepatitis better than previous animal models. Liver regeneration capacity was evaluated using: (1) The total number of Ki-67 positive hepatocytes in the caudate lobe, evaluated in a stereology based design; (2) the regenerated protein content to describe the regenerated liver mass; and (3) the plasma concentration of coagulation factors as a marker of liver function. We found a preserved liver regeneration capacity in rats with non-alcoholic steatohepatitis, adding important knowledge to the subject.
Publish Date	2018-01-26 08:09
Citation	Haldrup D, Heebøll S, Thomsen KL, Andersen KJ, Meier M, Mortensen FV, Nyengaard JR, Hamilton-Dutoit S, Grønbæk H. Preserved liver regeneration capacity after partial hepatectomy in rats with non-alcoholic steatohepatitis. World J Hepatol 2018; 10(1): 8-21
URL	http://www.wjgnet.com/1948-5182/full/v10/i1/8.htm
DOI	http://dx.doi.org/10.4254/wjh.v10.i1.8

Full Article (PDF)	WJH-10-8.pdf
Full Article (Word)	WJH-10-8.doc
Manuscript File	36309-Review.docx
Answering Reviewers	36309-Answering reviewers.pdf
Audio Core Tip	36309-Audio core tip.m4a
Biostatistics Review Certificate	36309-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	36309-Conflict-of-interest statement.pdf
Copyright License Agreement	36309-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	36309-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	36309-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	36309-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	36309-Non-Native-Speakers-of-English-Editing-Certificate-revision.docx
Supplementary Material	36309-Supplementary material.pdf
Peer-review Report	36309-Peer-review(s).pdf
Scientific Misconduct Check	36309-Scientific misconduct check.pdf
Scientific Editor Work List	36309-Scientific editor work list.pdf