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12/12/2017 8:34:14 AM | Browse: 996 | Download: 1332
Publication Name World Journal of Gastroenterology
Manuscript ID 36362
Country/Territory China
Received
2017-09-20 00:43
Peer-Review Started
2017-09-20 06:40
To Make the First Decision
2017-10-11 01:03
Return for Revision
2017-10-13 01:23
Revised
2017-10-24 09:55
Second Decision
2017-11-14 06:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-11-14 19:01
Articles in Press
2017-11-14 19:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-11-20 13:44
Typeset the Manuscript
2017-12-06 00:58
Publish the Manuscript Online
2017-12-12 08:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provide the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Integrative & Complementary Medicine
Manuscript Type Basic Study
Article Title Pharmacokinetics and pharmacodynamics of shengjiang decoction in rats with acute pancreatitis for protecting against multiple organ injuries
Manuscript Source Unsolicited Manuscript
All Author List Lv Zhu, Jun-Yi Li, Yu-Mei Zhang, Hong-Xin Kang, Huan Chen, Hang Su, Juan Li and Wen-Fu Tang
ORCID
Author(s) ORCID Number
Lv Zhu http://orcid.org/0000-0002-4302-3339
Jun-Yi Li http://orcid.org/0000-0003-2599-2889
Yu-Mei Zhang http://orcid.org/0000-0001-9802-776X
Hong-Xin Kang http://orcid.org/0000-0001-8212-0134
Huan Chen http://orcid.org/0000-0002-4763-6730
Hang Su http://orcid.org/0000-0003-2468-557X
Juan Li http://orcid.org/0000-0002-5775-9355
Wen-Fu Tang http://orcid.org/0000-0001-9294-6634
Funding Agency and Grant Number
Funding Agency Grant Number
the National Natural Science Foundation of China 81603519
the National Natural Science Foundation of China 81573857
the National Natural Science Foundation of China 81374042
Corresponding Author Wen-Fu Tang, PhD, Professor, Sichuan Provincial Pancreatitis Center, Department of Integrative Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, Sichuan Province, China. tangwf@scu.edu.cn
Key Words Shengjiang decoction; Pharmacokinetics; Pharmacodynamics; Pancreatic distribution; Acute pancreatitis
Core Tip Shengjiang decoction (SJD) has been identified effectively in treating acute pancreatitis (AP) in vivo and in vitro tests. We report the metabolic processes of major components of SJD in vivo and the pharmacodynamic mechanism of SJD in relieving AP the first time. This study demonstrated that AP may have varying effects on the pharmacokinetics of the major SJD components in rats. Rhein and bisdemethoxycurcumin may be potential active components for the treatment of AP based on the hypothesis of tissue pharmacology of herbal recipe. SJD may attenuate AP by regulating inflammatory responses to protect against multiple organ injuries.
Publish Date 2017-12-12 08:34
Citation Zhu L, Li JY, Zhang YM, Kang HX, Chen H, Su H, Li J, Tang WF. Pharmacokinetics and pharmacodynamics of Shengjiang decoction in rats with acute pancreatitis for protecting against multiple organ injury. World J Gastroenterol 2017; 23(46): 8169-8181
URL http://www.wjgnet.com/1007-9327/full/v23/i46/8169.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i46.8169
Full Article (PDF) WJG-23-8169.pdf
Full Article (Word) WJG-23-8169.doc
Manuscript File 36362-Review.doc
Answering Reviewers 36362-Answering reviewers.pdf
Audio Core Tip 36362-Audio core tip.mp3
Biostatistics Review Certificate 36362-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 36362-Conflict-of-interest statement.pdf
Copyright License Agreement 36362-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 36362-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 36362-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 36362-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 36362-Language certificate.pdf
Supplementary Material 36362-Supplementary-Material-revision.jpg
Peer-review Report 36362-Peer-review(s).pdf
Scientific Misconduct Check 36362-Scientific misconduct check.pdf
Scientific Editor Work List 36362-Scientific editor work list.pdf