ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Antifibrogenic effects of vitamin D derivatives on mouse pancreatic stellate cells
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Peter Wallbaum, Sarah Rohde, Luise Ehlers, Falko Lange, Alexander Hohn, Carina Bergner, Sarah Marie Schwarzenböck, Bernd Joachim Krause and Robert Jaster |
ORCID |
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Funding Agency and Grant Number |
Funding Agency |
Grant Number |
FORUN program of the Rostock University Medical Center |
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Corresponding Author |
Robert Jaster, MD, Academic Research, Professor, Senior Scientist, Department of Medicine II, Division of Gastroenterology, Rostock University Medical Center, E.-Heydemann-Str. 6, Rostock 18057, Germany. robert.jaster@med.uni-rostock.de |
Key Words |
Pancreatic stellate cells; Fibrosis; Vitamin D2; Vitamin D3; Calcipotriol |
Core Tip |
Modulation of the stroma response by vitamin D has been suggested as a concept to treat chronic pancreatitis and pancreatic cancer. Here we show that three derivatives, vitamin D2, vitamin D3 and calcipotriol, with similar efficiencies prevented pancreatic stellate cell (PSC) activation in vitro. Once the cells were fully activated, vitamin D failed to induce a reversal of the myofibroblastic phenotype, but still exerted antifibrotic effects by diminishing the uptake of proline and secretion of interleukin-6, an autocrine mediator of PSC activation. Our findings encourage further studies on the potential of vitamin D derivatives as antifibrotic drugs. |
Publish Date |
2018-01-14 05:07 |
Citation |
Wallbaum P, Rohde S, Ehlers L, Lange F, Hohn A, Bergner C, Schwarzenböck SM, Krause BJ, Jaster R. Antifibrogenic effects of vitamin D derivatives on mouse pancreatic stellate cells. World J Gastroenterol 2018; 24(2): 170-178 |
URL |
http://www.wjgnet.com/1007-9327/full/v24/i2/170.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v24.i2.170 |