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1/14/2018 5:07:58 AM | Browse: 1064 | Download: 992
Publication Name World Journal of Gastroenterology
Manuscript ID 36512
Country/Territory Germany
Received
2017-10-10 01:40
Peer-Review Started
2017-10-10 08:53
To Make the First Decision
2017-10-31 00:50
Return for Revision
2017-11-01 03:06
Revised
2017-11-15 07:53
Second Decision
2017-11-27 11:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-11-27 20:24
Articles in Press
2017-11-27 20:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-01-04 15:39
Publish the Manuscript Online
2018-01-14 05:07
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Antifibrogenic effects of vitamin D derivatives on mouse pancreatic stellate cells
Manuscript Source Unsolicited Manuscript
All Author List Peter Wallbaum, Sarah Rohde, Luise Ehlers, Falko Lange, Alexander Hohn, Carina Bergner, Sarah Marie Schwarzenböck, Bernd Joachim Krause and Robert Jaster
ORCID
Author(s) ORCID Number
Peter Wallbaum http://orcid.org/0000-0002-2270-6341
Sarah Rohde http://orcid.org/0000-0002-6892-1565
Luise Ehlers http://orcid.org/0000-0001-8565-0560
Falko Lange http://orcid.org/0000-0001-8782-5205
Alexander Hohn http://orcid.org/0000-0001-9637-6560
Carina Bergner http://orcid.org/0000-0001-7346-8067
Sarah Marie Schwarzenböck http://orcid.org/0000-0001-5138-7979
Bernd Joachim Krause http://orcid.org/0000-0002-2572-4131
Robert Jaster http://orcid.org/0000-0002-8220-4570
Funding Agency and Grant Number
Funding Agency Grant Number
FORUN program of the Rostock University Medical Center
Corresponding Author Robert Jaster, MD, Academic Research, Professor, Senior Scientist, Department of Medicine II, Division of Gastroenterology, Rostock University Medical Center, E.-Heydemann-Str. 6, Rostock 18057, Germany. robert.jaster@med.uni-rostock.de
Key Words Pancreatic stellate cells; Fibrosis; Vitamin D2; Vitamin D3; Calcipotriol
Core Tip Modulation of the stroma response by vitamin D has been suggested as a concept to treat chronic pancreatitis and pancreatic cancer. Here we show that three derivatives, vitamin D2, vitamin D3 and calcipotriol, with similar efficiencies prevented pancreatic stellate cell (PSC) activation in vitro. Once the cells were fully activated, vitamin D failed to induce a reversal of the myofibroblastic phenotype, but still exerted antifibrotic effects by diminishing the uptake of proline and secretion of interleukin-6, an autocrine mediator of PSC activation. Our findings encourage further studies on the potential of vitamin D derivatives as antifibrotic drugs.
Publish Date 2018-01-14 05:07
Citation Wallbaum P, Rohde S, Ehlers L, Lange F, Hohn A, Bergner C, Schwarzenböck SM, Krause BJ, Jaster R. Antifibrogenic effects of vitamin D derivatives on mouse pancreatic stellate cells. World J Gastroenterol 2018; 24(2): 170-178
URL http://www.wjgnet.com/1007-9327/full/v24/i2/170.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i2.170
Full Article (PDF) WJG-24-170.pdf
Full Article (Word) WJG-24-170.doc
Manuscript File 36512-Review.doc
Answering Reviewers 36512-Answering reviewers.pdf
Audio Core Tip 36512-Audio core tip.mp3
Biostatistics Review Certificate 36512-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 36512-Conflict-of-interest statement.pdf
Copyright License Agreement 36512-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 36512-Approved-Grant-Application-Form(s)-or-Funding-Agency-Copy-of-any-Approval-Document(s)-revision.pdf
Institutional Animal Care and Use Committee Approval Form or Document 36512-Institutional-Animal-Care-and-Use-Committee-Approval-Form-or-Document-revision.pdf
Institutional Review Board Approval Form or Document 36512-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 36512-Non-Native-Speakers-of-English-Editing-Certificate-revision.docx
Peer-review Report 36512-Peer-review(s).pdf
Scientific Misconduct Check 36512-Scientific misconduct check.pdf
Scientific Editor Work List 36512-Scientific editor work list.pdf