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4/11/2018 8:28:49 AM | Browse: 1098 | Download: 1653
Publication Name World Journal of Gastroenterology
Manuscript ID 36567
Country Japan
Received
2017-12-01 00:25
Peer-Review Started
2017-12-01 03:08
To Make the First Decision
2017-12-13 02:45
Return for Revision
2017-12-14 08:11
Revised
2018-02-06 16:54
Second Decision
2018-03-06 09:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-03-06 16:53
Articles in Press
2018-03-06 16:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-04-10 06:48
Publish the Manuscript Online
2018-04-11 08:28
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Randomized Controlled Trial
Article Title Maintenance for healed erosive esophagitis: Phase Ⅲ comparison of vonoprazan with lansoprazole
Manuscript Source Unsolicited Manuscript
All Author List Kiyoshi Ashida, Katsuhiko Iwakiri, Naoki Hiramatsu, Yuuichi Sakurai, Tetsuharu Hori, Kentarou Kudou, Akira Nishimura and Eiji Umegaki
ORCID
Author(s) ORCID Number
Kiyoshi Ashida http://orcid.org/0000-0002-5072-9399
Katsuhiko Iwakiri http://orcid.org/0000-0002-5558-6104
Naoki Hiramatsu http://orcid.org/0000-0002-8803-4488
Yuuichi Sakurai http://orcid.org/0000-0003-3337-8213
Tetsuharu Hori http://orcid.org/0000-0003-0638-6664
Kentarou Kudou http://orcid.org/0000-0003-0125-6174
Akira Nishimura http://orcid.org/0000-0001-6085-6829
Eiji Umegaki http://orcid.org/0000-0003-3353-8096
Funding Agency and Grant Number
Corresponding Author Kiyoshi Ashida, MD, PhD, Professor, Department of Gastroenterology, Rakuwakai Otowa Hospital, 2 Otowachinji-cho, Yamashina-ku 607-8062, Kyoto, Japan. rakuwadr1185@rakuwadr.com
Key Words Gastroesophageal reflux disease; Erosive esophagitis; Lansoprazole; Potassium-competitive acid blockers; Vonoprazan; Maintenance therapy
Core Tip Proton pump inhibitors (PPIs), including lanso­prazole, are widely used to maintain healing of erosive esophagitis (EE) in patients with gastroesophageal reflux disease; however, symptoms of reflux persist in significant numbers of patients treated with PPIs. We compared two doses of the novel potassium-competitive acid blocker vonoprazan (10 and 20 mg once daily) with lansoprazole at its approved dose of 15 mg once daily as maintenance therapy for healed EE in 607 Japanese patients. Vonoprazan was shown to be non-inferior to lansoprazole 15 mg at both investigated doses, while demonstrating a similar safety profile.
Publish Date 2018-04-11 08:28
Citation Ashida K, Iwakiri K, Hiramatsu N, Sakurai Y, Hori T, Kudou K, Nishimura A, Umegaki E. Maintenance for healed erosive esophagitis: Phase Ⅲ comparison of vonoprazan with lansoprazole. World J Gastroenterol 2018; 24(14): 1550-1561
URL http://www.wjgnet.com/1007-9327/full/v24/i14/1550.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i14.1550
Full Article (PDF) WJG-24-1550.pdf
Full Article (Word) WJG-24-1550.doc
CONSORT 2010 Statement 36567-CONSORT-2010-Statement-revision.pdf
Manuscript File 36567-Review.docx
Answering Reviewers 36567-Answering reviewers.pdf
Audio Core Tip 36567-Audio core tip.mp3
Biostatistics Review Certificate 36567-Biostatistics statement.pdf
Clinical Trial Registration Statement 36567-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 36567-Conflict-of-interest statement.pdf
Copyright License Agreement 36567-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 36567-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 36567-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 36567-Language certificate.pdf
Peer-review Report 36567-Peer-review(s).pdf
Scientific Misconduct Check 36567-Scientific misconduct check.pdf
Scientific Editor Work List 36567-Scientific editor work list.pdf