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Articles Published Processes
1/7/2018 4:21:05 AM | Browse: 1097 | Download: 1586
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Received |
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2017-11-02 17:55 |
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Peer-Review Started |
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2017-11-03 00:49 |
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To Make the First Decision |
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2017-11-14 07:14 |
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Return for Revision |
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2017-11-16 09:58 |
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Revised |
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2017-11-23 16:02 |
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Second Decision |
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2017-11-27 11:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2017-11-27 20:01 |
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Articles in Press |
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2017-11-27 20:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-12-14 11:35 |
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Typeset the Manuscript |
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2018-01-05 00:52 |
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Publish the Manuscript Online |
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2018-01-07 04:21 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Minireviews |
| Article Title |
Updated review on immune factors in pathogenesis of Crohn’s disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Na Li and Rui-Hua Shi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
8157041422 |
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| Corresponding Author |
Rui-Hua Shi, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, Zhongda Hospital, Affiliated Hospital of Southeast University, Dingjiaqiao Road 87, Nanjing 210009, Jiangsu Province, China. ruihuashi@126.com |
| Key Words |
pathogenesis; immune; immunotherapy; intestinal inflammation; Crohn’s disease; cytokines; lymphocytes; T lymphocytes |
| Core Tip |
It is now clear that Crohn's disease (CD) is an autoimmune disease that involves at least the intestinal mucosal immune system, when the mucosal immune system is invaded by food or bacterial antigens. However, it is worth mentioning that the mechanism remains unclear. Whether activation of the immune system is the internal defects (constitutive activation or regulation mechanism disorder) or changes in the epithelial mucosal barrier leading to continuous stimulation is still not clear. The mechanism of CD is intensively studied by domestic and foreign scholars on the immune destruction. Here we summarize the latest research status on immune factors in the pathogenesis of CD with regard to the mechanisms about T-lymphocyte immunity, innate lymphocyte immunity, cytokines and immune therapy. |
| Publish Date |
2018-01-07 04:21 |
| Citation |
Li N, Shi RH. Updated review on immune factors in pathogenesis of Crohn’s disease. World J Gastroenterol 2018; 24(1): 15-22 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i1/15.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i1.15 |
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