Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	36766
Country	China

Received	2017-10-23 02:39
Peer-Review Started	2017-10-25 01:10
To Make the First Decision	2017-11-09 08:40
Return for Revision	2017-11-10 00:56
Revised	2017-11-27 11:21
Second Decision	2017-12-01 08:24
Accepted by Journal Editor-in-Chief	2017-12-03 02:12
Accepted by Company Editor-in-Chief	2017-12-07 00:21
Articles in Press	2017-12-07 00:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-01-08 18:25
Publish the Manuscript Online	2018-01-12 09:26

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Advance in plasma SEPT9 gene methylation assay for colorectal cancer early detection
Manuscript Source	Unsolicited Manuscript
All Author List	Yu Wang, Pei-Min Chen and Rong-Bin Liu
ORCID	Author(s) ORCID Number Yu Wang http://orcid.org/0000-0002-0650-8126 Pei-Min Chen http://orcid.org/0000-0002-5337-9910 Rong-Bin Liu http://orcid.org/0000-0003-2170-7921
Funding Agency and Grant Number
Corresponding Author	Rong-Bin Liu, MD, Doctor, Department of Ultrasound, Sun Yat-sen Memorial Hospital, No. 107, Yanjiang West Road, Yuexiu District, Guangzhou 510120, China. liurb3@mail2.sysu.edu.cn
Key Words	Plasma; SEPT9; Methylation; Colorectal cancer; Early detection
Core Tip	The methylated SEPT9 gene has been implicated as a biomarker for colorectal cancer associated with the pathogenesis of colorectal cancer (CRC). In this article, we reviewed the literature on the correlation of SEPT9 gene and colorectal cancer and the theoretical basis of the SEPT9 gene methylation assay. Then, we focused on the diagnostic performance of the SEPT9 gene methylation assay for CRC by analyzing the clinical trial studies and compared that assay with other methods. Finally, we discussed the limitations of the SEPT9 gene methylation assay in clinical application. We hope that this article can provide a comprehensive overview of the progress achieved in the SEPT9 methylation assay for both the basic and clinical sciences.
Publish Date	2018-01-12 09:26
Citation	Wang Y, Chen PM, Liu RB. Advance in plasma SEPT9 gene methylation assay for colorectal cancer early detection. World J Gastrointest Oncol 2018; 10(1): 15-22
URL	http://www.wjgnet.com/1948-5204/full/v10/i1/15.htm
DOI	http://dx.doi.org/10.4251/wjgo.v10.i1.15

Full Article (PDF)	WJGO-10-15.pdf
Full Article (Word)	WJGO-10-15.doc
Manuscript File	36766-Review.docx
Answering Reviewers	36766-Answering reviewers.pdf
Audio Core Tip	36766-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	36766-Conflict-of-interest statement.pdf
Copyright License Agreement	36766-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	36766-Language certificate.pdf
Supplementary Material	36766-Supplementary material.pdf
Peer-review Report	36766-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	36766-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	36766-Scientific misconduct check.pdf
Scientific Editor Work List	36766-Scientific editor work list.pdf