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Articles Published Processes
9/11/2014 8:40:00 PM | Browse: 999 | Download: 956
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Received |
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2013-05-15 08:24 |
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Peer-Review Started |
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2013-05-15 14:32 |
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To Make the First Decision |
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2013-06-09 10:16 |
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Return for Revision |
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2013-06-18 12:53 |
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Revised |
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2013-07-20 17:25 |
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Second Decision |
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2013-08-20 10:21 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2013-08-20 12:39 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2013-11-04 09:46 |
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Publish the Manuscript Online |
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2013-12-18 09:53 |
Category |
Oncology |
Manuscript Type |
Autobiography |
Article Title |
Events associated with apoptotic effect of p-Coumaric acid in HCT-15 colon cancer cells
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Manuscript Source |
Invited Manuscript |
All Author List |
Saravana Kumar Jaganathan, Eko Supriyanto and Mahitosh Mandal |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Universiti Teknologi Malaysia, Malaysia for providing Visiting Research Fellowship |
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Corresponding Author |
Dr. Saravana Kumar Jaganathan, IJ N-UTM Cardiovascular Engineering Centre, Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru 81310, Malaysia. jaganathaniitkgp@gmail.com |
Key Words |
Honey; Apoptosis; Rhodamine-123; Sub-G1; Merocyanine; p-Coumaric acid; Reactive oxygen species |
Core Tip |
This article describes apoptotic effect of p-Coumaric acid, one of the phenolic components of honey, against colon cancer cells. p-Coumaric acid treatment resulted in the inhibition of proliferation and colony forming ability of human colorectal carcinoma (HCT-15) and HT 29 cells. Major events associated with growth-inhibition are increasing reactive oxygen species generation, increasing lipid layer breaks and a fall in Mitochondrial membrane potential. Further, membrane blebbing and shrinkage of p-Coumaric acid exposed HCT 15 cells insinuated apoptosis. Hence our results depicted that p-Coumaric acid is a prospective candidate for chemoprevention of colon cancer. |
Publish Date |
2013-12-18 09:53 |
Citation |
Jaganathan SK, Supriyanto E, Mandal M. Events associated with apoptotic effect of p-Coumaric acid in HCT-15 colon cancer cells. World J Gastroenterol 2013; 19(43): 7726-7734 |
URL |
http://www.wjgnet.com/1007-9327/full/v19/i43/7726.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v19.i43.7726 |
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