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2/9/2018 7:24:30 AM | Browse: 1070 | Download: 1547
Publication Name World Journal of Gastroenterology
Manuscript ID 37076
Country/Territory China
Received
2017-11-21 08:27
Peer-Review Started
2017-11-21 08:29
To Make the First Decision
2017-12-06 00:26
Return for Revision
2017-12-06 08:27
Revised
2017-12-12 18:35
Second Decision
2017-12-26 11:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-12-26 19:18
Articles in Press
2017-12-26 19:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-01-03 01:37
Typeset the Manuscript
2018-02-04 18:36
Publish the Manuscript Online
2018-02-09 07:24
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Metformin attenuates motility, contraction, and fibrogenic response of hepatic stellate cells in vivo and in vitro by activating AMP-activated protein kinase
Manuscript Source Unsolicited Manuscript
All Author List Zhen Li, Qian Ding, Li-Ping Ling, Ying Wu, Dong-Xiao Meng, Xiao Li and Chun-Qing Zhang
ORCID
Author(s) ORCID Number
Zhen Li http://orcid.org/0000-0003-1860-3048
Qian Ding http://orcid.org/0000-0002-2301-8487
Li-Ping Ling http://orcid.org/0000-0002-1738-830X
Ying Wu http://orcid.org/0000-0002-7813-7862
Dong-Xiao Meng http://orcid.org/0000-0003-4558-8760
Xiao Li http://orcid.org/0000-0003-1992-3529
Chun-Qing Zhang http://orcid.org/0000-0001-8711-1579
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China NO. 81370590
Corresponding Author Chun-Qing Zhang, PhD, Chief Doctor, Department of Gastroenterology, Shandong Provincial Hospital affiliated to Shandong University, 324 Jingwu Weiqi Road, Jinan 250021, Shandong Province, China. zhangchunqing_sdu@163.com
Key Words hepatic stellate cell; intrahepatic vascular resistance; angiogenesis; contraction; liver fibrosis; adenosine monophosphate-activated protein kinase
Core Tip Activation of hepatic stellate cells (HSCs) contributes to liver fibrosis and portal hypertension. In this study, we examined the effect of metformin on activated HSCs in vivo and in vitro. Metformin decreased the activation of HSCs, reduced the deposition of extracellular matrix (ECM), and inhibited angiogenesis in CCl4-treated mice. Moreover, metformin inhibited the activation, proliferation, motility, and contraction of activated HSCs, reduced the secretion of ECM, and decreased HSC-based angiogenesis, thus providing a new therapeutic approach to the treatment of liver fibrosis and portal hypertension.
Publish Date 2018-02-09 07:24
Citation Li Z, Ding Q, Ling LP, Wu Y, Meng DX, Li X, Zhang CQ. Metformin attenuates motility, contraction, and fibrogenic response of hepatic stellate cells in vivo and in vitro by activating AMP-activated protein kinase. World J Gastroenterol 2018; 24(7): 819-832
URL http://www.wjgnet.com/1007-9327/full/v24/i7/819.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i7.819
Full Article (PDF) WJG-24-819.pdf
Full Article (Word) WJG-24-819.doc
Manuscript File 37076-Review.docx
Answering Reviewers 37076-Answering reviewers.pdf
Audio Core Tip 37076-Audio core tip.mp3
Biostatistics Review Certificate 37076-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 37076-Conflict-of-interest statement.pdf
Copyright License Agreement 37076-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 37076-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 37076-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 37076-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 37076-Language certificate.pdf
Peer-review Report 37076-Peer-review(s).pdf
Scientific Misconduct Check 37076-Scientific misconduct check.pdf
Scientific Editor Work List 37076-Scientific editor work list.pdf