BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
3/6/2018 1:54:10 AM | Browse: 782 | Download: 1190
Publication Name World Journal of Nephrology
Manuscript ID 37509
Country/Territory Slovakia
Received
2017-12-13 16:44
Peer-Review Started
2017-12-13 23:46
To Make the First Decision
2017-12-26 00:23
Return for Revision
2017-12-27 03:12
Revised
2017-12-31 07:30
Second Decision
2018-01-25 09:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-02-05 01:07
Articles in Press
2018-02-05 01:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-03-05 03:03
Publish the Manuscript Online
2018-03-06 01:54
ISSN 2220-6124 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Urology & Nephrology
Manuscript Type Basic Study
Article Title Genetic defects in ciliary genes in autosomal dominant polycystic kidney disease
Manuscript Source Unsolicited Manuscript
All Author List Katarina Skalicka, Gabriela Hrčková, Anita Vaská, Ágnes Baranyaiová and László Kovács
ORCID
Author(s) ORCID Number
Katarina Skalicka http://orcid.org/0000-0001-8448-1603
Gabriela Hrčková http://orcid.org/0000-0002- 3333-7262
Anita Vaská http://orcid.org/0000-0002-2485-4399
Ágnes Baranyaiová http://orcid.org/0000-0001-9263-194X
László Kovács http://orcid.org/0000-0003-0641-811X
Funding Agency and Grant Number
Funding Agency Grant Number
Slovak Research and Development Agency under Contract APVV-14-0234
Corresponding Author Katarina Skalicka, MSc, PhD, Research Scientist, Laboratory of Clinical and Molecular Genetics, Department of Paediatrics, Faculty of Medicine, Comenius University and University Children’s Hospital, Limbova 1, Bratislava 83340, Slovakia. genlab@dfnsp.sk
Key Words Polycystic kidney disease; Primary cilium; Ciliary genes; Next-generation sequencing; Genetic variants
Core Tip Many studies have confirmed that the loss of primary cilia promotes renal cyst formation in autosomal dominant polycystic kidney disease (ADPKD). However, these studies are based on mouse models by the inactivation of various ciliary genes, and the actual status of these genes in human ADPKD tissues is unknown. In our study, we analyzed genetic defects in ciliary genes in the human polycystic kidney tissues and matched normal kidney tissues by next-generation sequencing. We found that the loss of the primary cilia in the human ADPKD tissues may be predominantly caused by defects of centrosomal proteins and KIF19 protein.
Publish Date 2018-03-06 01:54
Citation Skalická K, Hrčková G, Vaská A, Baranyaiová Á, Kovács L. Genetic defects in ciliary genes in autosomal dominant polycystic kidney disease. World J Nephrol 2018; 7(2): 65-70
URL http://www.wjgnet.com/2220-6124/full/v7/i2/65.htm
DOI http://dx.doi.org/10.5527/wjn.v7.i2.65
Full Article (PDF) WJN-7-65.pdf
Full Article (Word) WJN-7-65.doc
The ARRIVE Guidelines 37509-ARRIVE guidelines statement.pdf
Manuscript File 37509-Review.docx
Answering Reviewers 37509-Answering reviewers.pdf
Audio Core Tip 37509-Audio core tip.mp3
Biostatistics Review Certificate 37509-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 37509-Conflict-of-interest statement.pdf
Copyright License Agreement 37509-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 37509-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 37509-Institutional-Animal-Care-and-Use-Committee-Approval-Form-or-Document-revision.pdf
Institutional Review Board Approval Form or Document 37509-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 37509-Language certificate.pdf
Peer-review Report 37509-Peer-review(s).pdf
Scientific Misconduct Check 37509-Scientific misconduct check.pdf
Scientific Editor Work List 37509-Scientific editor work list.pdf