Publication Name	World Journal of Gastroenterology
Manuscript ID	38094
Country	China

Received	2018-03-29 07:18
Peer-Review Started	2018-03-30 07:06
To Make the First Decision	2018-05-17 03:14
Return for Revision	2018-05-21 02:45
Revised	2018-05-25 09:15
Second Decision	2018-06-08 08:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-06-09 04:35
Articles in Press	2018-06-09 04:35
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-06-19 20:01
Typeset the Manuscript	2018-07-09 07:53
Publish the Manuscript Online	2018-07-12 23:54

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Total polysaccharides of the Sijunzi decoction attenuate tumor necrosis factor-α-induced damage to the barrier function of a Caco-2 cell monolayer via the nuclear factor-κB-myosin light chain kinase-myosin light chain pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Yue Lu, Leng Li, Jin-Wei Zhang, Xiao-Qin Zhong, Jian-An Wei and Ling Han
ORCID	Author(s) ORCID Number Yue Lu http://orcid.org/0000-0002-5340-8398 Leng Li http://orcid.org/0000-0002-2011-7527 Jin-Wei Zhang http://orcid.org/0000-0003-2886-3222 Xiao-Qin Zhong http://orcid.org/0000-0002-2673-493X Jian-An Wei http://orcid.org/0000-0003-1556-1321 Ling Han http://orcid.org/0000-0002-6168-8828
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81202635 Guangdong Provincial Bureau of Chinese Medicine 20151244
Corresponding Author	Ling Han, PhD, Research Scientist, The Second Clinical College, Guangzhou University of Chinese Medicine, Inner ring western road, University Town, Guangzhou 510006, Guangdong Province, China. linghan99@gzucm.edu.cn
Key Words	Inflammatory bowel disease; tight junction; total polysaccharides of the Sijunzi decoction; Nuclear factor-κB pathway
Core Tip	Total polysaccharides of the Sijunzi decoction (TPSJ) comprise the active ingredient of Sijunzi decoction, which has long been used to treat gastrointestinal tract disorders. However, the mechanisms by which TPSJ af­fects the intestinal epithelial barrier remain unclear. Our study results demonstrated that TPSJ attenuated tumor necrosis factor (TNF)-α-induced intestinal barrier dys­function in a Caco-2 cell monolayer. Furthermore, TPSJ inhibited TNF-α-induced upregulation of myosin light chain (MLC) phosphorylation, which is mediated by MLC kinase and NF-κB, suggesting that this mechanism might underlie the protective effects of TPSJ against intestinal epithelial barrier dysfunction triggered by proinflammatory cytokines.
Publish Date	2018-07-12 23:54
Citation	Lu Y, Li L, Zhang JW, Zhong XQ, Wei JA, Han L. Total polysaccharides of the Sijunzi decoction attenuate tumor necrosis factor-α-induced damage to the barrier function of a Caco-2 cell monolayer via the nuclear factor-κB-myosin light chain kinase-myosin light chain pathway. World J Gastroenterol 2018; 24(26): 2867-2877
URL	http://www.wjgnet.com/1007-9327/full/v24/i26/2867.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i26.2867

Full Article (PDF)	WJG-24-2867.pdf
Manuscript File	38094-Review.doc
Answering Reviewers	38094-Answering reviewers.pdf
Audio Core Tip	38094-Audio core tip.mp3
Biostatistics Review Certificate	38094-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	38094-Conflict-of-interest statement.pdf
Copyright License Agreement	38094-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	38094-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	38094-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	38094-Language certificate.pdf
Peer-review Report	38094-Peer-review(s).pdf
Scientific Misconduct Check	38094-Scientific misconduct check.pdf
Scientific Editor Work List	38094-Scientific editor work list.pdf