ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Permissions |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Retrospective Study |
Article Title |
Intraoperative frozen section diagnosis of bile duct margin for extrahepatic cholangiocarcinoma
|
Manuscript Source |
Unsolicited Manuscript |
All Author List |
Takayuki Shiraki, Hajime Kuroda, Atsuko Takada, Yoshimasa Nakazato, Keiichi Kubota and Yasuo Imai |
ORCID |
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Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Ministry of Education, Culture, Sports, Science and Technology of Japan |
JP16K08695 |
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Corresponding Author |
Yasuo Imai, MD, PhD, Professor, Department of Diagnostic Pathology, Dokkyo Med Univ, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321-0293, Japan. ya-imai@dokkyomed.ac.jp |
Key Words |
Cholangiocarcinoma; Bile duct cancer; Frozen section diagnosis; Permanent section diagnosis; Bile duct margin; Biliary intraepithelial neoplasia; Dysplasia; Indefinite for neoplasia; Borderline lesion; Local recurrence |
Core Tip |
Usefulness of intraoperative frozen section diagnosis (FSD) of bile duct margin for extrahepatic cholangiocarcinoma was investigated. The diagnosis was classified into negative, borderline (biliary intraepithelial neoplasia-1 and 2, and indefinite for neoplasia), or positive, and FSD was compared with permanent section diagnosis postoperatively. In contrast to previous studies, positive FSD in the epithelial layer was significantly associated with local recurrence. Furthermore, borderline FSD in the epithelial layer could be substantially regarded as negative, which could aid surgeons to determine the resection range of the bile duct. Finally, we demonstrated that FSD was reliable enough for pathological diagnosis. |
Publish Date |
2018-03-26 08:48 |
Citation |
Shiraki T, Kuroda H, Takada A, Nakazato Y, Kubota K, Imai Y. Intraoperative frozen section diagnosis of bile duct margin for extrahepatic cholangiocarcinoma. World J Gastroenterol 2018; 24(12): 1332-1342 |
URL |
http://www.wjgnet.com/1007-9327/full/v24/i12/1332.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v24.i12.1332 |