| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Liver transplantation and alcoholic liver disease: History, controversies, and considerations
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Cláudio Augusto Marroni, Alfeu de Medeiros Fleck Jr, Sabrina Alves Fernandes, Lucas Homercher Galant, Marcos Mucenic, Mario Henrique de Mattos Meine, Guilherme Mariante-Neto and Ajacio Bandeira de Mello Brandão |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Cláudio Augusto Marroni, MD, PhD, Professor, Graduate Program in Medicine: Hepatology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Rua José Kanan Aranha, 102, Jardim Isabel, Porto Alegre 90430-080, RS, Brazil. nmarroni@terra.com.br |
| Key Words |
Alcoholic liver disease; Alcoholic hepatitis; Alcoholic cirrhosis; Alcoholism; Liver transplantation; Alcoholic recurrence; Controversies; Alcoholic abstinence; Relapse; Selection criteria |
| Core Tip |
Alcohol consumption accounts for 3.8% of annual global mortality worldwide. Cirrhosis is a common complication of alcoholic liver disease (ALD) and when end-stage liver disease is reached, the only chance of survival is liver transplantation (LT). There are controversies and ethical dilemmas associated with LT for ALD. This study reviews the history and controversies and considers the development of, indications for, and outcomes of LT in ALD, including severe acute alcoholic hepatitis. Relapse, therapeutic options, and outcomes are emphasized. |
| Publish Date |
2018-07-12 23:54 |
| Citation |
Marroni CA, Fleck Jr AM, Fernandes SA, Galant LH, Mucenic M, de Mattos Meine MH, Mariante-Neto G, Brandão ABM. Liver transplantation and alcoholic liver disease: history, controversies and considerations. World J Gastroenterol 2018; 24(26): 2785-2805 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i26/2785.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i26.2785 |
