Publication Name	World Journal of Gastroenterology
Manuscript ID	39042
Country	Poland

Received	2018-03-27 10:03
Peer-Review Started	2018-03-27 10:22
First Decision by Editorial Office Director	2018-04-18 13:55
Return for Revision	2018-04-21 09:16
Revised	2018-05-10 21:20
Publication Fee Transferred
Second Decision by Editor	2018-06-01 09:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2018-06-01 18:29
Articles in Press	2018-06-01 18:29
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-06-25 07:05
Publish the Manuscript Online	2018-06-26 00:26

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Hepatitis C virus infection in children in the era of direct-acting antiviral
Manuscript Source	Invited Manuscript
All Author List	Malgorzata Pawlowska, Malgorzata Sobolewska-Pilarczyk and Krzysztof Domagalski
ORCID	Author(s) ORCID Number Malgorzata Pawlowska http://orcid.org/0000-0002-6044-0425 Malgorzata Sobolewska-Pilarczyk http://orcid.org/0000-0002-8979-7655 Krzysztof Domagalski http://orcid.org/0000-0002-9766-8730
Funding Agency and Grant Number
Corresponding Author	Malgorzata Pawlowska, MD, PhD, Professor, Department of Paediatric Infectious Diseases and Hepatology, Faculty of Medicine, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University Torun, Floriana 12, Bydgoszcz 85-030, Poland. mpawlowska@cm.umk.pl
Key Words	Biomarkers of liver injury; Adolescents; Epidemiology; Direct-acting antiviral; Hepatitis C virus; Non-invasive methods; Children
Core Tip	There are more than 11 million hepatitis C virus (HCV)-infected children worldwide. Most new HCV-infected cases have occurred through vertical trans­mission. Currently, a new era of highly effective direct-acting antiviral agents for the treatment of HCV infection has begun for paediatric patients. The first results of clinical trials with interferon-free therapy are very pro­mising. ESPGHAN developed a position paper for the management of chronic HCV infection in children. Non-invasive methods to measure hepatic fibrosis enable the identification of patients with significant liver fibrosis. This article summarizes the current data on epidemiology, new therapies and non-invasive methods in paediatric patients with HCV infection.
Publish Date	2018-06-26 00:26
Citation	Pawlowska M, Sobolewska-Pilarczyk M, Domagalski K. Hepatitis C virus infection in children in the era of direct-acting antiviral. World J Gastroenterol 2018; 24(24): 2555-2566
URL	http://www.wjgnet.com/1007-9327/full/v24/i24/2555.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i24.2555

Full Article (PDF)	WJG-24-2555.pdf
Manuscript File	39042-Review.doc
Answering Reviewers	39042-Answering reviewers.pdf
Audio Core Tip	39042-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	39042-Conflict-of-interest statement.pdf
Copyright License Agreement	39042-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	39042-Language certificate.pdf
Peer-review Report	39042-Peer-review(s).pdf
Scientific Misconduct Check	39042-Scientific misconduct check.pdf