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Publication Name World Journal of Gastroenterology
Manuscript ID 39053
Country Spain
Received
2018-04-02 03:22
Peer-Review Started
2018-04-02 07:10
To Make the First Decision
2018-04-19 01:23
Return for Revision
2018-04-21 08:49
Revised
2018-04-21 17:37
Second Decision
2018-04-23 05:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-04-23 16:28
Articles in Press
2018-04-23 16:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-05-04 10:00
Publish the Manuscript Online
2018-05-06 13:12
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Is it possible to stop nucleos(t)ide analogue treatment in chronic hepatitis B patients?
Manuscript Source Invited Manuscript
All Author List Elia Moreno-Cubero, Robert Sánchez-del-Arco, Julia Peña-Asensio, Eduardo Sanz-de-Villalobos, Joaquín Miquel and Juan Ramón Larrubia
ORCID
Author(s) ORCID Number
Elia Moreno-Cubero http://orcid.org/0000-0001-7075-8392
Robert Sánchez-del-Arco http://orcid.org/0000-0003-4886-9154
Julia Peña-Asensio http://orcid.org/0000-0002-4220-1287
Eduardo Sanz-de-Villalobos http://orcid.org/0000-0001-7550-4359
Joaquín Miquel http://orcid.org/0000-0002-2367-8944
Juan Ramón Larrubia http://orcid.org/0000-0002-6383-848X
Funding Agency and Grant Number
Funding Agency Grant Number
Gilead Spain & Instituto de Salud Carlos III GLD14_00217
Gilead Spain & Instituto de Salud Carlos III GLD16_00014
Instituto de Salud Carlos III, Spain & European Regional Development Fund (ERDF), a way of making Europe PI12/00130
Instituto de Salud Carlos III, Spain & European Regional Development Fund (ERDF), a way of making Europe PI15/00074
Corresponding Author Juan Ramón Larrubia, MD, MSc, PhD, Senior Lecturer, Staff Physician, Translational Hepatology Unit, Guadalajara University Hospital, University of Alcalá, Donante de Sangre st, Guadalajara E-19002, Spain. juan.larrubia@uah.es
Key Words CD8; Lamivudine; Nucleos(t)ide analogues; Tenofovir; Chronic hepatitis B; Entecavir; hepatitis B virus; Treatment cessation
Core Tip Nucleos(t)ide analogue (NA) treatment effi­ciently suppress hepatitis B virus replication. However, hepatitis B surface antigen loss, the optimal endpoint of NA therapy, is rarely achieved. Thus, a major unmet need in the management of chronic hepatitis B is the definition of earlier and safe treatment stopping points. There is growing clinical evidence that the majority of patients can benefit from this strategy after long-term NA therapy; yet, no criteria that distinguish which cases can safely stop treatment is established. We review here different biomarkers that could serve as a prognostic tool to safely discontinue therapy, focusing on host antiviral immunity.
Publish Date 2018-05-06 13:12
Citation Moreno-Cubero E, Sánchez del Arco RT, Peña-Asensio J, Sanz de Villalobos E, Míquel J, Larrubia JR. Is it possible to stop nucleos(t)ide analogue treatment in chronic hepatitis B patients? World J Gastroenterol 2018; 24(17): 1825-1838
URL http://www.wjgnet.com/1007-9327/full/v24/i17/1825.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i17.1825
Full Article (PDF) WJG-24-1825.pdf
Manuscript File 39053-Review.doc
Answering Reviewers 39053-Answering reviewers.pdf
Audio Core Tip 39053-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 39053-Conflict-of-interest statement.pdf
Copyright License Agreement 39053-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 39053-Language certificate.pdf
Peer-review Report 39053-Peer-review(s).pdf
Scientific Misconduct Check 39053-Scientific misconduct check.pdf
Scientific Editor Work List 39053-Scientific editor work list.pdf