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Articles Published Processes
7/28/2020 2:46:56 PM | Browse: 684 | Download: 1413
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Received |
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2020-03-30 17:14 |
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Peer-Review Started |
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2020-03-30 17:17 |
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To Make the First Decision |
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Return for Revision |
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2020-04-25 03:58 |
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Revised |
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2020-06-08 02:49 |
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Second Decision |
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2020-07-14 09:55 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-07-14 23:34 |
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Articles in Press |
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2020-07-14 23:34 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-07-28 07:27 |
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Publish the Manuscript Online |
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2020-07-28 14:46 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Primary sclerosing cholangitis associated colitis: Characterization of clinical, histologic features, and their associations with liver transplantation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
John Aranake-Chrisinger, Themistocles Dassopoulos, Yan Yan and ILKe Nalbantoglu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
ILKe Nalbantoglu, MD, Associate Professor, Department of Surgical Pathology, Yale University School of Medicine, 20 York Street, EP2-608B, New Haven, CT, 06510, United States. ilke.nalbantoglu@yale.edu |
| Key Words |
Primary sclerosing cholangitis; Inflammatory bowel disease; Liver transplantation; Inflammation; Pathologic features; Clinical associations |
| Core Tip |
This is a retrospective study evaluating biopsies and clinical features of primary sclerosing cholangitis (PSC) patients with and without inflammatory bowel disease (IBD) in comparison to subjects with ulcerative colitis (UC) or Crohn disease (CD). Patients with PSC-UC had a different disease distribution characterized by right sided colitis, a milder disease course with lower activity scores in biopsies, less need for colectomy, and steroids compared to UC. PSC-CD patients were rare but had more ileal inflammation compared to PSC-UC. PSC-No IBD patients showed similar characteristics to PSC patients in general and only one patient received orthotopic liver transplantation (OLT) in this group. Ten PSC-UC patients received OLT in contrast to no patients with PSC-CD. The need for OLT in PSC-IBD (PSC-UC and PSC-CD) correlated with rectal involvement and higher activity scores in the left colon biopsies in comparison to patients without OLT. This may require clinical attention since the both the intestinal and liver disease seem to be “severe” in this group further supporting the importance of gut-liver interaction in these patients. |
| Publish Date |
2020-07-28 14:46 |
| Citation |
Aranake-Chrisinger J, Dassopoulos T, Yan Y, Nalbantoglu I. Primary sclerosing cholangitis associated colitis: Characterization of clinical, histologic features, and their associations with liver transplantation. World J Gastroenterol 2020; 26(28): 4126-4139 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i28/4126.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i28.4126 |
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