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8/3/2018 11:25:35 AM | Browse: 721 | Download: 955
Publication Name World Journal of Gastroenterology
Manuscript ID 39354
Country/Territory China
Received
2018-04-23 01:25
Peer-Review Started
2018-04-23 12:12
To Make the First Decision
2018-05-09 04:35
Return for Revision
2018-05-12 10:12
Revised
2018-06-03 07:30
Second Decision
2018-06-25 08:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-06-25 19:08
Articles in Press
2018-06-25 19:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-07-02 20:45
Typeset the Manuscript
2018-08-03 02:41
Publish the Manuscript Online
2018-08-03 11:25
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Research & Experimental Medicine
Manuscript Type Basic Study
Article Title Downregulation of Hes1 expression in experimental biliary atresia and its effects on bile duct structure
Manuscript Source Unsolicited Manuscript
All Author List Rui-Zhong Zhang, Xin-Hao Zeng, Ze-Feng Lin, Ming Fu, Yan-Lu Tong, Vincent CH Lui, Paul KH Tam, Jonathan R Lamb, Hui-Ming Xia and Yan Chen
ORCID
Author(s) ORCID Number
Rui-Zhong Zhang http://orcid.org/0000-0002-4954-7192
Xin-Hao Zeng http://orcid.org/0000-0002-3879-9810
Ze-Feng Lin http://orcid.org/0000-0001-7532-9175
Ming Fu http://orcid.org/0000-0003-1400-0258
Yan-Lu Tong http://orcid.org/0000-0003-0650-1562
Vincent CH Lui http://orcid.org/0000-0002-1758-8854
Paul KH Tam http://orcid.org/0000-0003-1596-4120
Jonathan R Lamb http://orcid.org/0000-0002-5497-392X
Hui-Ming Xia http://orcid.org/0000-0002-0103-1672
Yan Chen http://orcid.org/0000-0002-2354-230X
Funding Agency and Grant Number
Funding Agency Grant Number
Science and Technology Project of Guangzhou 201707010014
National Natural Science Foundation of China 81600399
National Natural Science Foundation of China 81671498
Corresponding Author Yan Chen, PhD, Honorary Research Fellow, Senior Scientist, Department of Surgery, the University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong , China. ychenc@hku.hk
Key Words Biliary atresia; Rhesus rotavirus; Hes1; EpCAM; Epithelial cells 3D culture
Core Tip Similar immature biliary epithelial cells and distorted bile ductules were observed in biliary atresia patients and a mouse biliary atresia model. Investigation of the Notch signaling pathway target gene Hes1 showed that mRNA and protein expression was reduced in mouse liver, which was partially due to reduced expression of transcriptional co-regulator RBP-Jκ. In biliary epithelial cells 3D gel culture system, the administration of Hes1 siRNA blocked the maturation and duct-like structure formation process, which resulted in the cells still being in an immature state and no duct-like structure was observed.
Publish Date 2018-08-03 11:25
Citation Zhang RZ, Zeng XH, Lin ZF, Fu M, Tong YL, Lui VC, Tam PK, Lamb JR, Xia HM, Chen Y. Downregulation of Hes1 expression in experimental biliary atresia and its effects on bile duct structure. World J Gastroenterol 2018; 24(29): 3260-3272
URL http://www.wjgnet.com/1007-9327/full/v24/i29/3260.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i29.3260
Full Article (PDF) WJG-24-3260.pdf
Full Article (Word) WJG-24-3260.doc
The ARRIVE Guidelines 39354-The ARRIVE Guidelines.pdf
Manuscript File 39354-Review.docx
Answering Reviewers 39354-Answering reviewers.pdf
Audio Core Tip 39354-Audio core tip.wav
Biostatistics Review Certificate 39354-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 39354-Conflict-of-interest statement.pdf
Copyright License Agreement 39354-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 39354-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 39354-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 39354-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 39354-Language certificate.pdf
Peer-review Report 39354-Peer-review(s).pdf
Scientific Misconduct Check 39354-Scientific misconduct check.pdf
Scientific Editor Work List 39354-Scientific editor work list.pdf