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Publication Name World Journal of Surgical Procedures
Manuscript ID 3946
Country/Territory Japan
Received
2013-06-04 08:30
Peer-Review Started
2013-06-04 16:09
To Make the First Decision
2013-06-24 10:32
Return for Revision
2013-07-17 15:24
Revised
2013-07-31 19:19
Second Decision
2013-09-16 14:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-09-17 05:44
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-10-10 15:43
Publish the Manuscript Online
2013-12-11 16:18
ISSN 2219-2832 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Minireviews
Article Title Platelet therapy: A novel strategy for liver regeneration, anti-fibrosis, and anti-apoptosis
Manuscript Source Invited Manuscript
All Author List Kazuhiro Takahashi, Soichiro Murata and Nobuhiro Ohkohchi
Funding Agency and Grant Number
Corresponding Author Nobuhiro Ohkohchi, MD, PhD, Professor, Department of Surgery, Division of Gastroenterological and Hepatobiliary Surgery and Organ Transplantation, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan. nokochi3@md.tsukuba.ac.jp
Key Words Platelet therapy; Liver regeneration; Liver fibrosis; Hepatocyte apoptosis; Growth factor
Core Tip Platelets have conventionally been considered to exacerbate the inflammatory response and liver injury. Recently, some studies have demonstrated a role for platelets in promoting liver regeneration, improving liver fibrosis, and attenuating hepatitis. In this review, the experimental and clinical evidence that platelets accelerate liver regeneration and attenuate fibrosis and apoptosis are described, as are the mechanisms of action. Platelet therapies, such as thrombopoietin, thrombopoietin receptor agonists, and platelet transfusion, will play a promising role in the treatment of the various liver disorders that currently challenge the surgical field.
Publish Date 2013-12-11 16:18
Citation Takahashi K, Murata S, Ohkohchi N. Platelet therapy: A novel strategy for liver regeneration, anti-fibrosis, and anti-apoptosis. World J Surg Proced 2013; 3(3): 29-36
URL http://www.wjgnet.com/2219-2832/full/v3/i3/29.htm
DOI http://dx.doi.org/10.5412/wjsp.v3.i3.29
Full Article (PDF) WJSP-3-29.pdf
Manuscript File 3946-Review.docx
Answering Reviewers 3946-Answering reviewers.pdf
Copyright License Agreement 3946-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 3946-Language certificate.pdf
Peer-review Report 3946-Peer reviewer(s).pdf
Scientific Editor Work List 3946-Scientific editor work list.doc