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Articles Published Processes
6/15/2018 3:55:56 AM | Browse: 874 | Download: 1217
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Received |
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2018-04-24 02:17 |
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Peer-Review Started |
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2018-04-24 09:25 |
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To Make the First Decision |
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2018-05-09 00:24 |
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Return for Revision |
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2018-05-09 02:10 |
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Revised |
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2018-05-10 10:10 |
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Second Decision |
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2018-05-15 11:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2018-05-15 17:35 |
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Articles in Press |
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2018-05-15 17:35 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-06-01 07:26 |
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Publish the Manuscript Online |
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2018-06-15 03:55 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Vishal J Patel, Amit A Joharapurkar, Samadhan G Kshirsagar, Brijesh K Sutariya, Maulik S Patel, Hiren M Patel, Dheerendra K Pandey, Rajesh H Bahekar and Mukul R Jain |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Amit A Joharapurkar, PhD, Senior Scientist, Department of Pharmacology and Toxicology, Zydus Research Centre, Cadila Healthcare Limited, Sarkhej-Bavla N.H.No.8A, Moraiya, Ahmedabad 382210, India. amitjoharapurkar@zyduscadila.com |
| Key Words |
Coagonist; Glucagon; Renal dysfunction; Glucagon-like peptide-1; Insulin sensitivity |
| Core Tip |
Nephropathy is a significant complication of diabetes. In this study, we have demonstrated that the coagonist of glucagon-like peptide-1 and glucagon receptors alleviates biochemical and histopathological features of nephropathy in HFSTZ and db/db mice. Coagonist reduces glucotoxicity and lipotoxicity in these animal models, which translates into benefit for prevention of nephropathy. The results provide further evidence that coagonist may be effective in the prevention of diabetic nephropathy. |
| Publish Date |
2018-06-15 03:55 |
| Citation |
Patel VJ, Joharapurkar AA, Kshirsagar SG, Sutariya BK, Patel MS, Patel HM, Pandey DK, Bahekar RH, Jain MR. Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus. World J Diabetes 2018; 9(6): 80-91 |
| URL |
http://www.wjgnet.com/1948-9358/full/v9/i6/80.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v9.i6.80 |
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