| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Total flavone of Abelmoschus manihot suppresses epithelial-mesenchymal transition via interfering transforming growth factor-β1 signaling in Crohn’s disease intestinal fibrosis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bo-Lin Yang, Ping Zhu, You-Ran Li, Min-Min Xu, Hao Wang, Lichao Qiao, Hai-Xia Xu and Hong-Jin Chen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Jiangsu Province, China |
BK2016157 |
| National Natural Science Foundation of China |
81673973 |
| Phase II Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions |
035062002003 |
| Developing Program for High-level Academic Talent in Jiangsu Hospital of TCM |
y2018rc16 |
|
| Corresponding Author |
Hong-Jin Chen, MD, Chief Doctor, Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Hanzhong 155 Rd, Nanjing 210029, Jiangsu, China. 260789@njucm.edu.cn |
| Key Words |
Crohn’s disease; Intestinal fibrosis; Epithelial-to-mesenchymal transition; Total flavone of Abelmoschus manihot; Transforming growth factor-β1/Smad signaling; Transforming growth factor-β1/non-Smad signaling |
| Core Tip |
Regulating transforming growth factor-β (TGF-β) and its downstream signaling pathways, mediating the epithelial-mesenchymal transition (EMT) process and restoring the biological function of abnormally activated intestinal fibroblasts, may be an important way to seek drug therapy for Crohn’s disease (CD) intestinal fibrosis. Total flavone of Abelmoschus manihot (TFA) can inhibit TGF-β1-induced morphological change, migration, invasion of rat intestinal epithelial cells, and promote induction of EMT partially by inhibiting TGF-β1-activated Smad and non-Smad signaling pathways. Therefore, TFA is expected to advance as a new therapy to treat CD intestinal fibrosis, and its continued advancement may open the door to a new class of treatment for CD intestinal fibrosis. |
| Publish Date |
2018-08-13 07:45 |
| Citation |
Yang BL, Zhu P, Li YR, Xu MM, Wang H, Qiao LC, Xu HX, Chen HJ. Total flavone of Abelmoschus manihot suppresses epithelial-mesenchymal transition via interfering transforming growth factor-β1 signaling in Crohn’s disease intestinal fibrosis. World J Gastroenterol 2018; 24(30): 3414-3425 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i30/3414.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i30.3414 |
