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9/1/2014 10:21:00 AM | Browse: 458 | Download: 368
Publication Name World Journal of Critical Care Medicine
Manuscript ID 3991
Country of Manuscript Source Canada
2013-06-06 20:20
Peer-Review Started
2013-06-07 11:18
To Make the First Decision
2013-07-19 08:49
Return for Revision
2013-07-20 23:30
Second Decision
2013-12-13 13:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-12-13 14:25
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-01-26 16:48
Publish the Manuscript Online
2014-02-16 13:23
ISSN 2220-3141(online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Critical Care Medicine
Manuscript Type Minireviews
Article Title Controversies in fluid therapy: Type, dose and toxicity
Manuscript Source Invited Manuscript
All Author List Robert C McDermid, Karthik Raghunathan, Adam Romanovsky, Andrew D Shaw and Sean M Bagshaw
Funding Agency and Grant Number
Funding Agency Grant Number
Canada Research Chair in Critical Care Nephrology
Clinical Investigator Award from Alberta Innovates-Health Solutions (to Bagshaw MS)
Corresponding author Dr. Sean M Bagshaw, Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, 3C1.12 Walter C. Mackenzie Centre, 8440-122 ST NW, Edmonton, AB T6G2B7, Canada. bagshaw@ualberta.ca
Keywords Fluid therapy; Resuscitation; Critical illness; Peri-operative; Toxicity; Saline; Crystalloid; Colloid
Core Tip Fluid therapy is exceedingly common in acutely ill patients; however, numerous questions on the efficacy and safety of fluid therapy in terms of the type and dose remain. Fluid therapy prescription is context-specific and any fluid type can be harmful if administered inappropriately. When considering crystalloids versus colloids, differences in efficacy are modest but the risk of kidney toxicity and bleeding complications with hydroxyethyl starch appear more significant. The differences in chloride load across crystalloid solutions appears to have physiologic and clinically important effects, in particular for contributing to hyperchloremic metabolic acidosis, kidney injury and greater utilization of renal replacement therapy associated with 0.9% saline. Fluid therapy should be viewed as analogous to the prescription of any drug in acutely ill patients.
Publish Date 2014-02-16 13:23
Citation McDermid RC, Raghunathan K, Romanovsky A, Shaw AD, Bagshaw SM. Controversies in fluid therapy: Type, dose and toxicity. World J Crit Care Med 2014; 3(1): 24-33 Available from: URL: http://www.wjgnet.com/2220-3141/full/v3/i1/24.htm DOI: http:// dx.doi.org/10.5492/wjccm.v3.i1.24
Url http://www.wjgnet.com/2220-3141/full/v3/i1/24.htm
DOI http://dx.doi.org/10.5492/wjccm.v3.i1.24
Full Article (PDF) WJCCM-3-24.pdf
Full Article (Word) WJCCM-3-24.doc
Manuscript File 3991-Review.doc
Answering Reviewers 3991-Answering reviewers.pdf
Copyright License Agreement 3991-Copyright assignment.pdf
Peer-review Report 3991-Peer reviewer(s).pdf
Scientific Editor Work List 3991-Scientific editor work list.doc