| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Association between Helicobacter pylori, Epstein-Barr virus, human papillomavirus and gastric adenocarcinomas
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Carolina Rosal Teixeira de Souza, Marcelli Carolini Alves Almeida, André Salim Khayat, Emerson Lucena da Silva, Paulo Cardoso Soares, Luiz Claudio Chaves and Rommel Rodríguez Burbano |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The National Council for Scientific and Technological Development (CNPq) |
402283/2013-9 |
|
| Corresponding Author |
Carolina Rosal Teixeira de Souza, PhD, Adjunct Professor, Laboratory of Human Cytogenetics, Institute of Biological Sciences, Federal University of Pará, Rua Augusto Corrêa, 1 - Guamá,, Pará 66075-110, Belém, Brazil. carolrosalts@gmail.com |
| Key Words |
Gastric cancer; Gastric adenocarcinomas; Microorganisms; Helicobacter pylori; cagA; Epstein-Barr virus; Human papillomavirus |
| Core Tip |
We investigated the presence of Helicobacter pylori (H. pylori), Epstein-Barr virus (EBV) and human papillomavirus in gastric adenocarcinomas and their relationships with the clinicopathological characteristics of the patients. Despite the fact that all three pathogens were found in the samples, we believe that only H. pylori and EBV contribute to the transformation of tissue associated with carcinogenesis. A significant association between the cagA gene of H. pylori and EBV was also observed. Given this finding, the use of prophylactic and therapeutic measures against both H. pylori and EBV may help to prevent the development of gastric cancer, especially the more aggressive forms. |
| Publish Date |
2018-11-21 04:08 |
| Citation |
de Souza CR, Almeida MC, Khayat AS, da Silva EL, Soares PC, Chaves LC, Burbano RM. Association between Helicobacter pylori, Epstein-Barr virus, and human papillomavirus and gastric adenocarcinomas. World J Gastroenterol 2018; 24(43): 4928-4938 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i43/4928.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i43.4928 |
