Publication Name	World Journal of Cardiology
Manuscript ID	40072
Country	Italy

Received	2018-05-29 08:41
Peer-Review Started	2018-05-29 09:02
To Make the First Decision	2018-06-15 02:33
Return for Revision	2018-06-19 01:26
Revised	2018-06-20 06:28
Second Decision	2018-06-27 08:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-06-28 17:28
Articles in Press	2018-06-28 17:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-10-17 07:51
Publish the Manuscript Online	2018-10-26 14:42

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Editorial
Article Title	T-cells in myocardial infarction: Culprit instigators or mere effectors?
Manuscript Source	Invited Manuscript
All Author List	Luca Liberale, Aldo Bonaventura and Fabrizio Montecucco
ORCID	Author(s) ORCID Number Luca Liberale http://orcid.org/0000-0003-1472-7975 Aldo Bonaventura http://orcid.org/0000-0002-4747-5535 Fabrizio Montecucco http://orcid.org/0000-0003-0823-8729
Funding Agency and Grant Number
Corresponding Author	Luca Liberale, MD, Postdoctoral Fellow, First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, Genoa 16132, Italy. luca.liberale@uzh.ch
Key Words	Matrix metalloproteinase; Lymphocytes; Autoimmunity; Inflammation; Myocardial infarction; Adaptive immunity
Core Tip	CD31 and matrix metalloproteinases (MMP)-9 are known mediators that are upregulated during reperfusion after cardiac ischemia. By inhibiting T-cell receptor-dependent lymphocyte activation, the functional CD31 could reduce post-ischemic inflammatory res¬ponse; while MMP-9 is deeply involved in inflammatory cell recruitment and myocardial remodeling. A recent paper published in European Heart Journal linked these mediators by showing CD31 cleavage to be MMP-9 dependent in patients with acute coronary syndromes (ACS). Whether this process is causative of ACS or rather its effect still needs to be clarified.
Publish Date	2018-10-26 14:42
Citation	Liberale L, Bonaventura A, Montecucco F. T-cells in myocardial infarction: Culprit instigators or mere effectors? World J Cardiol 2018; 10(10): 123-126
URL	http://www.wjgnet.com/1949-8462/full/v10/i10/123.htm
DOI	http://dx.doi.org/10.4330/wjc.v10.i10.123

Full Article (PDF)	WJC-10-123.pdf
Full Article (Word)	WJC-10-123.doc
Manuscript File	40072-Review.docx
Answering Reviewers	40072-Answering reviewers.pdf
Audio Core Tip	40072-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	40072-Conflict-of-interest statement.pdf
Copyright License Agreement	40072-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	40072-Approved-Grant-Application-Form(s)-or-Funding-Agency-Copy-of-any-Approval-Document(s)-revision.docx
Non-Native Speakers of English Editing Certificate	40072-Language certificate.pdf
Peer-review Report	40072-Peer-review(s).pdf
Scientific Misconduct Check	40072-Scientific misconduct check.pdf
Scientific Editor Work List	40072-Scientific editor work list.pdf