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11/21/2018 4:08:59 AM | Browse: 130 | Download: 73
Publication Name World Journal of Gastroenterology
Manuscript ID 40527
Country of Manuscript Source China
Received
2018-07-07 14:52
Peer-Review Started
2018-07-09 00:31
To Make the First Decision
2018-08-31 00:38
Return for Revision
2018-08-31 02:26
Revised
2018-09-27 04:47
Second Decision
2018-10-15 08:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-10-15 18:23
Articles in Press
2018-10-15 18:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-11-05 21:08
Typeset the Manuscript
2018-11-15 01:01
Publish the Manuscript Online
2018-11-21 04:08
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Basic Study
Article Title Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer
Manuscript Source Invited Manuscript
All Author List Wen-Yan Xu, Qiang-Sheng Hu, Yi Qin, Bo Zhang, Wen-Sheng Liu, Quan-Xing Ni, Jin Xu and Xian-Jun Yu
ORCID
Author(s) ORCID Number
Wen-Yan Xu http://orcid.org/0000-0003-1855-6245
Qiang-Sheng Hu http://orcid.org/0000-0001-7469-1359
Yi Qin http://orcid.org/0000-0001-9804-202X
Bo Zhang http://orcid.org/0000-0002-2808-2242
Wen-Sheng Liu http://orcid.org/0000-0003-4357-1893
Quan-Xing Ni http://orcid.org/0000-0003-1877-8067
Jin Xu http://orcid.org/0000-0002-2942-8604
Xian-Jun Yu http://orcid.org/0000-0002-6697-7143
Funding Agency and Grant Number
Funding Agency Grant Number
National Science Fund for Distinguished Young Scholars of China 81625016
National Science Foundation of China 81502031 and 81772555
Shanghai Municipal Commission of Health and Family Planning Grant 20154Y0090
Youth Research Foundation of Shanghai Municipal Commission of Health and Family Planning Z0124Y074
Correspondence To Xian-Jun Yu, MD, PhD, Professor, Surgeon, Surgical Oncologist, Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, No. 270 DongAn Road, Xuhui District, Shanghai 200032, China. yuxianjun@fudanpci.org
Keywords Pancreatic cancer; Zinc finger E-box binding homeobox-1; Sirtuin 3; Methyl-CpG binding domain protein 1; Glycolysis
Core Tip Recent studies have demonstrated the impact of aerobic glycolysis on oncogenesis, proliferation, progression, and metastasis of cancer cells. Zinc finger E-box binding homeobox-1 (ZEB1) is an important regulator of metastasis and progression of pancreatic cancer, but its role in aerobic glycolysis has seldom been discussed. Our results demonstrated that ZEB1 is an important regulator of aerobic glycolysis. It has been demonstrated that ZEB1 regulates aerobic glycolysis by suppression of sirtuin 3 via interaction with methyl-CpG binding domain protein 1. Our results shed light on novel aspects and targets for treatment of pancreatic cancer.
Publish Date 2018-11-21 04:08
Citation Xu WY, Hu QS, Qin Y, Zhang B, Liu WS, Ni QX, Xu J, Yu XJ. Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer. World J Gastroenterol 2018; 24(43): 4893-4905
Url http://www.wjgnet.com/1007-9327/full/v24/i43/4893.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i43.4893
Full Article (PDF) WJG-24-4893.pdf
Full Article (Word) WJG-24-4893.doc
Manuscript File 40527-Review.docx
Answering Reviewers 40527-Answering reviewers.pdf
Audio Core Tip 40527-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 40527-Conflict-of-interest statement.pdf
Copyright License Agreement 40527-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 40527-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 40527-Language certificate.pdf
Peer-review Report 40527-Peer-review(s).pdf
Scientific Misconduct Check 40527-Scientific misconduct check.pdf
Scientific Editor Work List 40527-Scientific editor work list.pdf