Publication Name	World Journal of Gastroenterology
Manuscript ID	40598
Country	Canada

Received	2018-07-05 00:16
Peer-Review Started	2018-07-05 02:46
To Make the First Decision	2018-07-25 00:46
Return for Revision	2018-07-25 02:52
Revised	2018-07-30 17:55
Second Decision	2018-07-31 12:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-08-01 04:15
Articles in Press	2018-08-01 04:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-09-27 05:49
Publish the Manuscript Online	2018-09-30 07:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Focus on the gut-brain axis: Multiple sclerosis, the intestinal barrier and the microbiome
Manuscript Source	Invited Manuscript
All Author List	Carlos Rodrigo Camara-Lemarroy, Luanne Metz and V Wee Yong
ORCID	Author(s) ORCID Number Carlos Rodrigo Camara-Lemarroy http://orcid.org/0000-0003-0676-6675 Luanne Metz http://orcid.org/0000-0002-9868-6842 V Wee Yong http://orcid.org/0000-0002-2600-3563
Funding Agency and Grant Number
Corresponding Author	Carlos Rodrigo Camara-Lemarroy, MD, Academic Fellow, Postdoctoral Fellow, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, 1403 29 Street NW, Calgary T2N 2T9, Alberta, Canada. carlos.camara-lemarroy@albertahealthservices.ca
Key Words	Multiple sclerosis; Microbiome; Intestinal barrier; Bile acids; Gut-brain axis
Core Tip	Many studies suggest that the brain-gut connection can contribute to our knowledge of the pathophysiology of neurological conditions. Recent evidence suggests that people with multiple sclerosis have changes in their gut microbiome, their intestinal barrier and even in the metabolism of bile acids. All of these represent relevant therapeutic targets that could feasibly be addressed by pre-clinical and clinical studies. This knowledge acquired in the bench might soon be translated to the bedside.
Publish Date	2018-09-30 07:38
Citation	Camara-Lemarroy CR, Metz LM, Yong VW. Focus on the gut-brain axis: Multiple sclerosis, the intestinal barrier and the microbiome. World J Gastroenterol 2018; 24(37): 4217-4223
URL	http://www.wjgnet.com/1007-9327/full/v24/i37/4217.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i37.4217

Full Article (PDF)	WJG-24-4217.pdf
Full Article (Word)	WJG-24-4217.doc
Manuscript File	40598-Review.docx
Answering Reviewers	40598-Answering reviewers.pdf
Audio Core Tip	40598-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	40598-Conflict-of-interest statement.pdf
Copyright License Agreement	40598-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	40598-Grant application form(s).pdf
Peer-review Report	40598-Peer-review(s).pdf
Scientific Misconduct Check	40598-Scientific misconduct check.pdf
Scientific Editor Work List	40598-Scientific editor work list.pdf