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9/12/2014 8:41:00 PM | Browse: 1203 | Download: 736
Publication Name World Journal of Gastroenterology
Manuscript ID 4063
Country/Territory United States
Received
2013-06-13 08:57
Peer-Review Started
2013-06-13 09:38
To Make the First Decision
2013-07-05 18:24
Return for Revision
2013-07-15 10:36
Revised
2013-07-17 06:37
Second Decision
2013-08-06 13:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-08-06 23:07
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-08-30 09:51
Publish the Manuscript Online
2013-09-14 11:17
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Minireviews
Article Title Appendectomy and Clostridium difficile colitis: Relationships revealed by clinical observations and immunology
Manuscript Source Invited Manuscript
All Author List Nathan L Sanders, R Randal Bollinger, Ryan Lee, Steven Thomas and William Parker
Funding Agency and Grant Number
Corresponding Author William Parker, PhD, Department of Surgery, Duke University Medical Center, 200 Trent Dr, Durham, NC 27710, United States. bparker@duke.edu
Key Words Appendectomy; Clostridium difficile; Colitis; Diarrheal illness; Vermiform appendix
Core Tip Although the function of the appendix has remained an enigma for centuries, recently emerging advances in the fields of immunology and gut microbiology have merged with observations made in the clinic to form a coherent picture. Although the appendix is apparently a safe-house for beneficial bacteria, it seems likely that this safe-house does not satisfactorily protect the microbiome from broad spectrum antibiotics. In this view, selection pressures which threatened the microbiome and likely drove the evolution of the appendix have been supplanted in post-industrial society by new threats to the microbiome that the human body is not adapted for.
Publish Date 2013-09-14 11:17
Citation Sanders NL, Bollinger RR, Lee R, Thomas S, Parker W. Appendectomy and Clostridium difficile colitis: Relationships revealed by clinical observations and immunology. World J Gastroenterol 2013; 19(34): 5607-5614
URL http://www.wjgnet.com/1007-9327/full/v19/i34/5607.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i34.5607
Full Article (PDF) WJG-19-5607.pdf
Manuscript File 4063-Review.docx
Answering Reviewers 4063-Answering reviewers.pdf
Copyright License Agreement 4063-Copyright assignment.pdf
Peer-review Report 4063-Peer reviews.pdf
Scientific Editor Work List 4063-Scientific editor work list.doc