Category |
Gastroenterology & Hepatology |
Manuscript Type |
Autobiography |
Article Title |
De novo combined lamivudine and adefovir dipivoxil therapy vs entecavir monotherapy for hepatitis B virus-related decompensated cirrhosis
|
Manuscript Source |
Invited Manuscript |
All Author List |
Jiang-Shan Lian, Lin-Yan Zeng, Jian-Yang Chen, Hong-Yu Jia, Yi-Min Zhang, Dai-Rong Xiang, Liang Yu, Jian-Hua Hu, Ying-Feng Lu, Ling Zheng, Lan-Juan Li and Yi-Da Yang |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Key Program for Infectious Diseases of China |
2013ZX10002001 (to Yang YD) |
12th Five-Year Significant New Drugs Creation Plan of the Ministry of Science and Technology of China |
2011ZX09302-003-03 (to Yang YD) |
|
Corresponding Author |
Dr. Yi-Da Yang, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. yangyida65@163.com |
Key Words |
Chronic hepatitis B; Decompensated liver cirrhosis; Lamivudine; Adefovir dipivoxil; Combination therapy; Entecavir |
Core Tip |
This study compared the de novo efficacy of combined lamivudine (LAM) and adefovir dipivoxil (ADV) therapy with that of entecavir (ETV) monotherapy for patients with hepatitis B virus (HBV)-related decompensated liver cirrhosis. Both LAM + ADV combination therapy and ETV monotherapy can effectively inhibit HBV replication, improve liver function, and decrease mortality. The data obtained in this study demonstrate the efficacy and the safety of these treatment regimens for 96 wk in patients with HBV-related decompensated liver cirrhosis. |
Publish Date |
2013-10-18 17:02 |
Citation |
Lian JS, Zeng LY, Chen JY, Jia HY, Zhang YM, Xiang DR, Yu L, Hu JH, Lu YF, Zheng L, Li LJ, Yang YD. De novo combined lamivudine and adefovir dipivoxil therapy vs entecavir monotherapy for hepatitis B virus-related decompensated cirrhosis. World J Gastroenterol 2013; 19(37): 6278-6283 |
URL |
http://www.wjgnet.com/1007-9327/full/v19/i37/6278.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v19.i37.6278 |