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10/12/2018 5:32:21 AM | Browse: 931 | Download: 1196
Publication Name World Journal of Gastroenterology
Manuscript ID 40791
Country/Territory Germany
Received
2018-07-16 05:07
Peer-Review Started
2018-07-16 07:15
To Make the First Decision
2018-08-01 02:44
Return for Revision
2018-08-01 08:06
Revised
2018-08-03 15:14
Second Decision
2018-08-20 06:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-08-24 09:10
Articles in Press
2018-08-24 09:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-10-10 01:53
Publish the Manuscript Online
2018-10-12 05:32
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Analysis of the nitric oxide-cyclic guanosine monophosphate pathway in experimental liver cirrhosis suggests phosphodiesterase-5 as potential target to treat portal hypertension
Manuscript Source Invited Manuscript
All Author List Denise Schaffner, Adhara Lazaro, Peter Deibert, Peter Hasselblatt, Patrick Stoll, Lisa Fauth, Manfred W Baumstark, Irmgard Merfort, Annette Schmitt-Graeff and Wolfgang Kreisel
ORCID
Author(s) ORCID Number
Denise Schaffner http://orcid.org/0000-0001-6173-9288
Adhara Lazaro http://orcid.org/0000-0001-9023-1387
Peter Deibert http://orcid.org/0000-0002-3291-884X
Peter Hasselblatt http://orcid.org/0000-0002-1107-6516
Patrick Stoll http://orcid.org/0000-0001-8133-2071
Lisa Fauth http://orcid.org/0000-0001-5183-7140
Manfred W Baumstark http://orcid.org/0000-0002-5442-1586
Irmgard Merfort http://orcid.org/0000-0003-4716-5016
Annette Schmitt-Graeff http://orcid.org/0000-0001-5082-7979
Wolfgang Kreisel http://orcid.org/0000-0001-6884-0135
Funding Agency and Grant Number
Corresponding Author Wolfgang Kreisel, MD, Emeritus Professor, Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, Freiburg 79106, Germany. wolfgang.kreisel@uniklinik-freiburg.de
Key Words Portal hypertension; Thioacetamide; Nitric oxide; Liver cirrhosis; Cyclic guanosine monophosphate; Phosphodiesterase-5; Sildenafil; Hepatic stellate cells; Metabolic zonation
Core Tip A constriction of sinusoids plays an im­portant role in the pathogenesis of cirrhotic portal hypertension, wherein the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway plays a pivotal role. In a rat model of liver cirrhosis phosphodiesterase-5 (PDE-5) was markedly overexpressed both on the mRNA and the protein level. PDE-5 converts the vasodilating cGMP to inactive 5’-GMP. In healthy liver a zonation of PDE-5 was found which is abrogated in cirrhosis. Serum cGMP was reduced in cirrhosis. Inhibition of PDE-5 by Sildenafil normalized serum cGMP levels and lowered portal venous pressure. Hence, the inhibition of PDE-5 may be a promising adjunct in portal hypertension therapy.
Publish Date 2018-10-12 05:32
Citation Schaffner D, Lazaro A, Deibert P, Hasselblatt P, Stoll P, Fauth L, Baumstark MW, Merfort I, Schmitt-Graeff A, Kreisel W. Analysis of the nitric oxide-cyclic guanosine monophosphate pathway in experimental liver cirrhosis suggests phosphodiesterase-5 as potential target to treat portal hypertension. World J Gastroenterol 2018; 24(38): 4356-4368
URL http://www.wjgnet.com/1007-9327/full/v24/i38/4356.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i38.4356
Full Article (PDF) WJG-24-4356.pdf
The ARRIVE Guidelines 40791-The ARRIVE guidelines.pdf
Manuscript File 40791-Review.docx
Answering Reviewers 40791-Answering reviewers.pdf
Audio Core Tip 40791-Audio core tip.MOV
Biostatistics Review Certificate 40791-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 40791-Conflict-of-interest statement.pdf
Copyright License Agreement 40791-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 40791-Approved-Grant-Application-Form(s)-or-Funding-Agency-Copy-of-any-Approval-Document(s)-revision.docx
Institutional Animal Care and Use Committee Approval Form or Document 40791-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 40791-Institutional-Review-Board-Approval-Form-or-Document-revision.pdf
Non-Native Speakers of English Editing Certificate 40791-Language certificate.pdf
Video 40791-Video-revision.docx
Supplementary Material 40791-Supplementary-Material-revision.docx
Peer-review Report 40791-Peer-review(s).pdf
Scientific Misconduct Check 40791-Scientific misconduct check.pdf
Scientific Editor Work List 40791-Scientific editor work list.pdf