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2/26/2019 3:18:49 AM | Browse: 216 | Download: 120
Publication Name World Journal of Stem Cells
Manuscript ID 40966
Country/Territory United Kingdom
2018-07-24 02:18
Peer-Review Started
2018-07-24 05:59
To Make the First Decision
2018-10-08 07:32
Return for Revision
2018-10-10 01:15
2018-12-11 11:02
Second Decision
2018-12-29 01:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-01-01 17:06
Articles in Press
2019-01-01 17:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-01-22 18:19
Typeset the Manuscript
2019-02-25 10:20
Publish the Manuscript Online
2019-02-26 03:18
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Basic Study
Article Title Anti-inflammatory potential of human corneal stroma-derived stem cells determined by a novel in vitro corneal epithelial injury model
Manuscript Source Invited Manuscript
All Author List Mariana Lizeth Orozco Morales, Nagi M Marsit, Owen D McIntosh, Andrew Hopkinson and Laura E Sidney
Author(s) ORCID Number
Mariana Lizeth Orozco Morales http://orcid.org/0000-0002-8287-753X
Nagi M Marsit http://orcid.org/0000-0003-2952-7896
Owen D McIntosh http://orcid.org/0000-0001-5184-6055
Andrew Hopkinson http://orcid.org/0000-0002-8801-7485
Laura E Sidney http://orcid.org/0000-0003-1466-7597
Funding Agency and Grant Number
Corresponding author Laura E Sidney, MSc, PhD, Senior Research Fellow, Academic Ophthalmology, Division of Clinical Neuroscience, University of Nottingham, Queen’s Medical Centre Campus, Nottingham NG7 2UH, United Kingdom. laura.sidney@nottingham.ac.uk
Key Words Cornea; Corneal injuries; Injury model; Corneal epithelium; Corneal stroma-derived stem cells; Amnion; Anti-inflammatory; Cell therapy
Core Tip We designed a novel in vitro inflammation model of the human corneal surface using human corneal epithelial cells treated with 20% (v/v) ethanol, followed by stimulation with 1 ng/mL interleukin-1β. We then used this model to demonstrate the anti-inflammatory and regenerative healing properties of human cornea stroma-derived stem cells seeded on an amniotic membrane substrate, in a co-culture model. This study is the first step in building a topical regenerative therapy for the treatment of inflammatory disorders of the front of the eye.
Publish Date 2019-02-26 03:18
Citation Orozco Morales ML, Marsit NM, McIntosh OD, Hopkinson A, Sidney LE. Anti-inflammatory potential of human corneal stroma-derived stem cells determined by a novel in vitro corneal epithelial injury model. World J Stem Cells 2019; 11(2): 84-99
Url https://www.wjgnet.com/1948-0210/full/v11/i2/84.htm
DOI https://dx.doi.org/10.4252/wjsc.v11.i2.84
Full Article (PDF) WJSC-11-84.pdf
Full Article (Word) WJSC-11-84.docx
Manuscript File FP6742_de16_CE1MS_edit2.docx
Answering Reviewers 40966-Answering-Reviewers-revision.docx
Audio Core Tip 40966-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 40966-Conflict-of-interest statement.pdf
Copyright License Agreement 40966-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 40966-Institutional review board statement.pdf
Peer-review Report 40966-Peer-review(s).pdf
Scientific Misconduct Check 40966-Scientific misconduct check.pdf
Scientific Editor Work List 40966-Scientific editor work list.pdf