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8/26/2014 4:36:00 PM | Browse: 890 | Download: 712
Publication Name World Journal of Gastroenterology
Manuscript ID 4099
Country/Territory China
Received
2013-06-14 08:59
Peer-Review Started
2013-06-16 10:08
To Make the First Decision
2013-07-05 18:25
Return for Revision
2013-07-14 21:10
Revised
2013-09-27 13:38
Second Decision
2013-11-05 11:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-11-05 12:27
Articles in Press
2014-06-06 11:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-04-06 10:19
Typeset the Manuscript
2014-05-19 14:02
Publish the Manuscript Online
2014-06-06 16:55
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Physiology
Manuscript Type Autobiography
Article Title Investigation of cholecystokinin receptors in the human lower esophageal sphincter
Manuscript Source Invited Manuscript
All Author List Jun-Feng Liu, Jian Zhang, Xin-Bo Liu and Paul A Drew
Funding Agency and Grant Number
Funding Agency Grant Number
Government Foundation Grant from Hebei Provincial Department of Education HBGX2005-52
National Natural Science Foundation of China 30371413
Corresponding Author Jun-Feng Liu, PhD, Professor, Department of Thoracic Surgery, Fourth Hospital, Hebei Medical University, 12 Jiankang Road, Shijiazhuang 050011, Hebei Province, China. liujf@heinfo.net
Key Words Cholecystokinins; Cholecystokinins-A receptor; Cholecystokinins-B receptor; Radioligand binding; Lower esophageal sphincter; Sling fibers; Clasp fibers
Core Tip We isolated the sling and clasp muscles which help form the human lower esophageal sphincter. The expression of cholecystokinin (CCK)-A and CCK-B receptors was measured in the two muscles. The binding of 3H-CCK-8S to the CCK receptors was studied to determine the binding characteristics of the hormone to the receptor subtypes. It is concluded that the CCK-A receptor probably plays a more important role than the CCK-B receptor in mediating the contractile function of lower esophageal sphincter, through a combination of more receptors and a stronger binding affinity.
Publish Date 2014-06-06 16:55
Citation Liu JF, Zhang J, Liu XB, Drew PA. Investigation of cholecystokinin receptors in the human lower esophageal sphincter. World J Gastroenterol 2014; 20(21): 6554-6559
URL http://www.wjgnet.com/1007-9327/full/v20/i21/6554.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i21.6554
Full Article (PDF) WJG-20-6554.pdf
Full Article (Word) WJG-20-6554.doc
Manuscript File 4099-Review.doc
Answering Reviewers 4099-Answering reviewers.pdf
Copyright License Agreement 4099-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 4099-Language certificate.pdf
Peer-review Report 4099-Peer reviews.pdf
Scientific Editor Work List 4099-Scientific editor work list.doc