BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
11/6/2018 10:20:22 AM | Browse: 842 | Download: 1367
Publication Name World Journal of Clinical Cases
Manuscript ID 41072
Country/Territory Spain
Received
2018-07-23 00:43
Peer-Review Started
2018-07-23 07:01
To Make the First Decision
2018-08-30 01:57
Return for Revision
2018-08-30 02:40
Revised
2018-09-03 20:36
Second Decision
2018-09-06 11:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-10-09 14:40
Articles in Press
2018-10-09 14:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-10-22 04:52
Typeset the Manuscript
2018-10-31 08:33
Publish the Manuscript Online
2018-11-06 10:20
ISSN 2307-8960 (online)
Open Access Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Retrospective Cohort Study
Article Title Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding
Manuscript Source Unsolicited Manuscript
All Author List José Ignacio Fortea, Ángela Puente, Patricia Ruiz, Iranzu Ezcurra, Javier Vaquero, Antonio Cuadrado, María Teresa Arias-Loste, Joaquín Cabezas, Susana Llerena, Paula Iruzubieta, Carlos Rodríguez-Lope, Patricia Huelin, Fernando Casafont, Emilio Fábrega and Javier Crespo
ORCID
Author(s) ORCID Number
José Ignacio Fortea http://orcid.org/0000-0001-5255-9445
Ángela Puente http://orcid.org/0000-0002-8533-2412
Patricia Ruiz http://orcid.org/0000-0002-3440-0438
Iranzu Ezcurra http://orcid.org/0000-0001-5115-1878
Javier Vaquero http://orcid.org/0000-0001-8903-7288
Antonio Cuadrado http://orcid.org/0000-0002-1363-864X
María Teresa Arias-Loste http://orcid.org/0000-0001-8864-3833
Joaquín Cabezas http://orcid.org/0000-0003-0012-484X
Susana Llerena http://orcid.org/0000-0002-5882-8404
Paula Iruzubieta http://orcid.org/0000-0001-9476-1801
Carlos Rodríguez-Lope http://orcid.org/0000-0002-6713-8800
Patricia Huelin http://orcid.org/0000-0003-2340-4772
Fernando Casafont http://orcid.org/0000-0002-3866-465X
Emilio Fábrega http://orcid.org/0000-0002-8694-8307
Javier Crespo http://orcid.org/0000-0001-8248-0172
Funding Agency and Grant Number
Funding Agency Grant Number
Instituto de Investigación Sanitaria Marqués de Valdecilla NVAL17/07
Instituto Carlos III PI15/01083
Corresponding Author José Ignacio Fortea, MD, PhD, Attending Doctor, Research Scientist, Servicio de Aparato Digestivo, Hospital Universitario Marques de Valdecilla, Av. Valdecilla s/n, Santander 39008, Cantabria, Spain. jifortea@gmail.com
Key Words Gastrointestinal hemorrhage; Propranolol; Carvedilol; Liver cirrhosis; Portal hypertension
Core Tip In patients with cirrhosis treated with traditional nonselective beta-blockers (NSBBs) (i.e. propranolol and nadolol), the lack of acute hemodynamic response to intravenous propranolol has been consistently associated with a higher risk of decompensation and death. More¬over, carvedilol is more effective than traditional NSBB in reducing portal pressure. In the present study, we evaluated for the first time the clinical impact of an acute hemodynamic response-guided protocol for the primary prophylaxis of variceal bleeding in which acute hemodynamic responders were treated with traditional NSBB and acute nonresponders with carvedilol. Im¬portantly, the risk of decompensation and survival were similar in both groups, strongly suggesting that carvedilol improved the long-term outcome of acute nonresponders.
Publish Date 2018-11-06 10:20
Citation Fortea JI, Puente Á, Ruiz P, Ezcurra I, Vaquero J, Cuadrado A, Arias-Loste MT, Cabezas J, Llerena S, Iruzubieta P, Rodríguez-Lope C, Huelin P, Casafont F, Fábrega E, Crespo J. Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding. World J Clin Cases 2018; 6(13): 611-623
URL http://www.wjgnet.com/2307-8960/full/v6/i13/611.htm
DOI http://dx.doi.org/10.12998/wjcc.v6.i13.611
Full Article (PDF) WJCC-6-611.pdf
Full Article (Word) WJCC-6-611.doc
STROBE Statement 41072-STROBE statement.pdf
Manuscript File 41072-Review.docx
Answering Reviewers 41072-Answering reviewers.pdf
Audio Core Tip 41072-Audio core tip.mp3
Biostatistics Review Certificate 41072-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 41072-Conflict-of-interest statement.pdf
Copyright License Agreement 41072-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 41072-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 41072-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 41072-Language certificate.pdf
Peer-review Report 41072-Peer-review(s).pdf
Scientific Misconduct Check 41072-Scientific misconduct check.pdf
Scientific Editor Work List 41072-Scientific editor work list.pdf