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Articles Published Processes
11/21/2018 4:08:59 AM | Browse: 836 | Download: 912
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Received |
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2018-08-09 00:22 |
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Peer-Review Started |
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2018-08-09 07:09 |
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To Make the First Decision |
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2018-10-08 03:47 |
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Return for Revision |
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2018-10-08 08:07 |
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Revised |
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2018-10-22 14:22 |
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Second Decision |
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2018-11-02 09:05 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2018-11-02 17:02 |
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Articles in Press |
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2018-11-02 17:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-11-10 05:25 |
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Publish the Manuscript Online |
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2018-11-21 04:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Promoting genetics in non-alcoholic fatty liver disease: Combined risk score through polymorphisms and clinical variables
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Umberto Vespasiani-Gentilucci, Paolo Gallo, Chiara Dell'Unto, Mara Volpentesta, Raffaele Antonelli-Incalzi and Antonio Picardi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Antonio Picardi, MD, PhD, Professor, Unit of Internal Medicine and Hepatology, Department of Medicine, University Campus Bio-Medico, Via Alvaro del Portillo 200, Rome 00128, Italy. a.picardi@unicampus.it |
| Key Words |
Non-alcoholic fatty liver disease; Single nucleotide polymorphism; Patatin-like phospholipase domain-containing protein 3; Transmembrane 6 superfamily member 2; Membrane bound O-acyltransferase domain containing 7; Glucokinase regulatory gene; Risk score; Non-alcoholic steatohepatitis; Non-alcoholic steatohepatitis cirrhosis; Hepatocellular carcinoma |
| Core Tip |
Risk stratification is emerging as fundamental in the non-alcoholic fatty liver disease (NAFLD) epidemic. Due to the strong heritability of hepatic fat content and of liver fibrosis progression, genetics is perfectly suitable to fulfill this task. However, notwithstanding the fact that different gene variants have been robustly associated with NAFLD and with its evolution, translation to the clinical ground has been poor or absent. The evidence produced suggests that combined risk scores, created by integrating different genetic and clinical information and tested with respect to relevant outcomes in longitudinal studies, may represent the way for genetics to gain strength in NAFLD diagnostics. |
| Publish Date |
2018-11-21 04:08 |
| Citation |
Vespasiani-Gentilucci U, Gallo P, Dell’Unto C, Volpentesta M, Antonelli-Incalzi R, Picardi A. Promoting genetics in non-alcoholic fatty liver disease: Combined risk score through polymorphisms and clinical variables. World J Gastroenterol 2018; 24(43): 4835-4845 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i43/4835.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i43.4835 |
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