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11/26/2018 6:01:26 AM | Browse: 354 | Download: 415
Publication Name World Journal of Stem Cells
Manuscript ID 41507
Country/Territory Japan
2018-08-10 09:42
Peer-Review Started
2018-08-13 09:13
To Make the First Decision
2018-08-27 01:35
Return for Revision
2018-09-03 01:08
2018-09-07 11:55
Second Decision
2018-09-19 08:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-10-12 02:07
Articles in Press
2018-10-12 02:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-11-20 06:14
Publish the Manuscript Online
2018-11-26 06:01
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Cytokines in adipose-derived mesenchymal stem cells promote the healing of liver disease
Manuscript Source Invited Manuscript
All Author List Saifun Nahar, Yoshiki Nakashima, Chika Miyagi-Shiohira, Takao Kinjo, Zensei Toyoda, Naoya Kobayashi, Issei Saitoh, Masami Watanabe, Hirofumi Noguchi and Jiro Fujita
Author(s) ORCID Number
Saifun Nahar http://orcid.org/0000-0003-4696-617X
Yoshiki Nakashima http://orcid.org/0000-0003-1827-7609
Chika Miyagi-Shiohira http://orcid.org/0000-0003-0061-585X
Takao Kinjo http://orcid.org/0000-0002-5316-4071
Zensei Toyoda http://orcid.org/0000-0002-2667-0446
Naoya Kobayashi http://orcid.org/0000-0003-2638-3102
Issei Saitoh http://orcid.org/0000-0002-7451-0666
Masami Watanabe http://orcid.org/0000-0003-1268-1029
Hirofumi Noguchi http://orcid.org/0000-0002-0880-6805
Jiro Fujita http://orcid.org/0000-0003-3423-8343
Funding Agency and Grant Number
Funding Agency Grant Number
Japan Society for the Promotion of Science KAKENHI Grant Number JP16H05404
Japan Society for the Promotion of Science KAKENHI Grant Number JP16K10435
Japan Society for the Promotion of Science KAKENHI Grant Number JP18K08545
Japan Agency for Medical Research and Development
The Naito Foundation
Okinawa Science and Technology Promotion Center (OSTC)
Corresponding Author Hirofumi Noguchi, MD, PhD, Professor, Department of Regenerative Medicine, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan. noguchih@med.u-ryukyu.ac.jp
Key Words Cell transplantation therapy; Cytokine; Hepatocytes; Liquid chromatography with tandem mass spectrometry; Liver cirrhosis; Adipose-derived mesenchymal stem cells
Core Tip We previously showed that conditioned medium of adipose-derived mesenchymal stem cells (ADSCs) promoted hepatocyte proliferation and im­proved the liver function in a mouse model of acute liver failure. Furthermore, as reported by many other groups, the administration of ADSCs improved liver tissue fibrosis in a mouse model of liver cirrhosis. A comprehensive protein expression analysis by liquid ch­romatography with tandem mass spectrometry showed that the various cytokines and chemokines produced by ADSCs have the ability to promote the healing of liver disease. In this review, we examine the ability of the expressed protein components of ADSCs to promote healing in cell therapy for liver disease.
Publish Date 2018-11-26 06:01
Citation Nahar S, Nakashima Y, Miyagi-Shiohira C, Kinjo T, Toyoda Z, Kobayashi N, Saitoh I, Watanabe M, Noguchi H, Fujita J. Cytokines in adipose-derived mesenchymal stem cells promote the healing of liver disease. World J Stem Cells 2018; 10(11): 146-159
Url http://www.wjgnet.com/1948-0210/full/v10/i11/146.htm
DOI http://dx.doi.org/10.4252/wjsc.v10.i11.146
Full Article (PDF) WJSC-10-146.pdf
Full Article (Word) WJSC-10-146.doc
Manuscript File 41507-Review.docx
Answering Reviewers 41507-Answering reviewers.pdf
Audio Core Tip 41507-Audio core tip.wma
Biostatistics Review Certificate 41507-Biostatistics Review Certificate.pdf
Conflict-of-Interest Disclosure Form 41507-Conflict-of-interest statement.pdf
Copyright License Agreement 41507-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 41507-Approved-Grant-Application-Form(s)-or-Funding-Agency-Copy-of-any-Approval-Document(s)-revision.pdf
Institutional Animal Care and Use Committee Approval Form or Document 41507-Institutional Animal Care and Use Committee Approval Form or Document.pdf
Institutional Review Board Approval Form or Document 41507-Institutional Review Board Approval Form or Document.pdf
Non-Native Speakers of English Editing Certificate 41507-Language certificate.pdf
Peer-review Report 41507-Peer-review(s).pdf
Scientific Misconduct Check 41507-Scientific misconduct check.pdf
Scientific Editor Work List 41507-Scientific editor work list.pdf