| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Cytokines in adipose-derived mesenchymal stem cells promote the healing of liver disease
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Saifun Nahar, Yoshiki Nakashima, Chika Miyagi-Shiohira, Takao Kinjo, Zensei Toyoda, Naoya Kobayashi, Issei Saitoh, Masami Watanabe, Hirofumi Noguchi and Jiro Fujita |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Japan Society for the Promotion of Science |
KAKENHI Grant Number JP16H05404 |
| Japan Society for the Promotion of Science |
KAKENHI Grant Number JP16K10435 |
| Japan Society for the Promotion of Science |
KAKENHI Grant Number JP18K08545 |
| Japan Agency for Medical Research and Development |
|
| The Naito Foundation |
|
| Okinawa Science and Technology Promotion Center (OSTC) |
|
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| Corresponding Author |
Hirofumi Noguchi, MD, PhD, Professor, Department of Regenerative Medicine, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan. noguchih@med.u-ryukyu.ac.jp |
| Key Words |
Cell transplantation therapy; Cytokine; Hepatocytes; Liquid chromatography with tandem mass spectrometry; Liver cirrhosis; Adipose-derived mesenchymal stem cells |
| Core Tip |
We previously showed that conditioned medium of adipose-derived mesenchymal stem cells (ADSCs) promoted hepatocyte proliferation and improved the liver function in a mouse model of acute liver failure. Furthermore, as reported by many other groups, the administration of ADSCs improved liver tissue fibrosis in a mouse model of liver cirrhosis. A comprehensive protein expression analysis by liquid chromatography with tandem mass spectrometry showed that the various cytokines and chemokines produced by ADSCs have the ability to promote the healing of liver disease. In this review, we examine the ability of the expressed protein components of ADSCs to promote healing in cell therapy for liver disease. |
| Publish Date |
2018-11-26 06:01 |
| Citation |
Nahar S, Nakashima Y, Miyagi-Shiohira C, Kinjo T, Toyoda Z, Kobayashi N, Saitoh I, Watanabe M, Noguchi H, Fujita J. Cytokines in adipose-derived mesenchymal stem cells promote the healing of liver disease. World J Stem Cells 2018; 10(11): 146-159 |
| URL |
http://www.wjgnet.com/1948-0210/full/v10/i11/146.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v10.i11.146 |
