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11/27/2018 5:55:53 AM | Browse: 763 | Download: 1010
Publication Name World Journal of Gastroenterology
Manuscript ID 41540
Country/Territory China
Received
2018-08-20 00:49
Peer-Review Started
2018-08-20 02:53
To Make the First Decision
2018-10-08 03:35
Return for Revision
2018-10-11 00:48
Revised
2018-10-14 15:01
Second Decision
2018-11-07 09:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-11-08 02:39
Articles in Press
2018-11-08 02:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-11-14 07:49
Typeset the Manuscript
2018-11-27 01:59
Publish the Manuscript Online
2018-11-27 05:55
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Involvement of methylation-associated silencing of formin 2 in colorectal carcinogenesis
Manuscript Source Unsolicited Manuscript
All Author List Dao-Jiang Li, Zhi-Cai Feng, Xiao-Rong Li and Gui Hu
ORCID
Author(s) ORCID Number
Dao-Jiang Li http://orcid.org/0000-0003-0986-4190
Zhi-Cai Feng http://orcid.org/0000-0003-2485-7466
Xiao-Rong Li http://orcid.org/0000-0001-8585-3632
Gui Hu http://orcid.org/0000-0002-0901-9686
Funding Agency and Grant Number
Funding Agency Grant Number
National Nature Science Foundation of China No. 81773130
The New Xiangya Talent Projects of the Third Xiangya Hospital of Central South University No.JY201508
The Key Projects of Postgraduate Independent Exploration and Innovation of The Central South University 2018zzts050
Corresponding Author Gui Hu, PhD, Surgeon, Department of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Tongzi Po Road, No. 172, Changsha 410013, Hunan Province, China. xy3zzz@csu.edu.cn
Key Words Formin 2; Colorectal cancer; Methylation; Methylation-associated silencing; Early-stage cancer
Core Tip Colorectal cancer (CRC) is the leading cause of cancer death in the world. We identified a statistically significant downregulation of formin 2 (FMN2) expression in large-scale human CRC expression datasets and our clinical samples. Then, we first showed that a high fre­quency of hypermethylation occurred in the FMN2 gene promoter, which is responsible for the downregulation of FMN2 expression. Additionally, the highest methylation of FMN2 occurred in tissues from cases of early-stage CRC and patients > 60 years old. FMN2 hypermethylation may be an important early event in CRC and can serve as an ideal diagnostic biomarker in elderly patients with early-stage CRC.
Publish Date 2018-11-27 05:55
Citation Li DJ, Feng ZC, Li XR, Hu G. Involvement of methylation-associated silencing of formin 2 in colorectal carcinogenesis. World J Gastroenterol 2018; 24(44): 5013-5024
URL http://www.wjgnet.com/1007-9327/full/v24/i44/5013.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i44.5013
Full Article (PDF) WJG-24-5013.pdf
Full Article (Word) WJG-24-5013.doc
The ARRIVE Guidelines 41540-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 41540-Review.docx
Answering Reviewers 41540-Answering reviewers.pdf
Audio Core Tip 41540-Audio core tip.m4a
Biostatistics Review Certificate 41540-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 41540-Conflict-of-interest statement.pdf
Copyright License Agreement 41540-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 41540-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 41540-Institutional-Animal-Care-and-Use-Committee-Approval-Form-or-Document-revision.pdf
Institutional Review Board Approval Form or Document 41540-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 41540-Language certificate.pdf
Supplementary Material 41540-Supplementary-Material-revision.pdf
Peer-review Report 41540-Peer-review(s).pdf
Scientific Misconduct Check 41540-Scientific misconduct check.pdf
Scientific Editor Work List 41540-Scientific editor work list.pdf