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11/7/2018 2:30:08 AM | Browse: 274 | Download: 205
Publication Name World Journal of Gastroenterology
Manuscript ID 41605
Country/Territory Italy
2018-08-18 08:40
Peer-Review Started
2018-08-19 03:21
To Make the First Decision
2018-10-08 02:59
Return for Revision
2018-10-09 02:11
2018-10-11 20:15
Second Decision
2018-10-19 09:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-10-21 06:38
Articles in Press
2018-10-21 06:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-11-06 03:50
Publish the Manuscript Online
2018-11-07 02:30
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, General and Internal
Manuscript Type Editorial
Article Title Chronic hepatitis C, atherosclerosis and cardiovascular disease: What impact of direct-acting antiviral treatments?
Manuscript Source Invited Manuscript
All Author List Luigi Elio Adinolfi, Luca Rinaldi and Riccardo Nevola
Author(s) ORCID Number
Luigi Elio Adinolfi http://orcid.org/0000-0001-8453-4912
Luca Rinaldi http://orcid.org/0000-0002-6541-3821
Riccardo Nevola http://orcid.org/0000-0003-3320-3878
Funding Agency and Grant Number
Corresponding author Luigi Elio Adinolfi, MD, Full Professor, Professor, Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, University of Campania “L. Vanvitelli”, Piazza Miraglia, Naples 80138, Italy. luigielio.adinolfi@unicampania.it
Keywords Direct-acting antiviral agents; Hepatitis C virus; Atherosclerosis; Insulin resistance; Cardiovascular disease
Core Tip Chronic hepatitis C (HCV) infection is associated with an increased risk of atherosclerosis, cardiovascular disease and cardiovascular mortality. HCV lives within carotid plaques, promotes pro-atherogenic conditions such as pro-inflammatory cytokines, oxidative stress, insulin resistance, diabetes, steatosis, cryoglobulinemia and endotoxinemia. Direct-acting antiviral agents (DAA) are highly effective and safe therapeutic regimens. There are a number of studies showing that HCV clearance by DAAs is associated with an improvement in atherosclerosis and a reduced risk of cardiovascular events. In addition, HCV clearance is associated with improvement of metabolic and immunological conditions that promote cardiovascular disease. Further studies will be needed to confirm these promising data.
Publish Date 2018-11-07 02:30
Citation Adinolfi LE, Rinaldi L, Nevola R. Chronic hepatitis C, atherosclerosis and cardiovascular disease: What impact of direct-acting antiviral treatments? World J Gastroenterol 2018; 24(41): 4617-4621
Url http://www.wjgnet.com/1007-9327/full/v24/i41/4617.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i41.4617
Full Article (PDF) WJG-24-4617.pdf
Manuscript File 41605-Review.docx
Answering Reviewers 41605-Answering reviewers.pdf
Audio Core Tip 41605-Audio core tip.3gp
Conflict-of-Interest Disclosure Form 41605-Conflict-of-interest statement.pdf
Copyright License Agreement 41605-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 41605-Non-Native-Speakers-of-English-Editing-Certificate-revision.docx
Peer-review Report 41605-Peer-review(s).pdf
Scientific Misconduct Check 41605-Scientific misconduct check.pdf
Scientific Editor Work List 41605-Scientific editor work list.pdf